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Selective determination of trace thiamphenicol in milk and honey by molecularly imprinted polymer monolith microextraction and high-performance liquid chromatography.
MedLine Citation:
PMID:  22102397     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A novel solid-phase microextraction (SPME) method based on molecularly imprinted polymer (MIP) monolith as the sorbent for the selective extraction of thiamphenicol (TAP) in milk and honey was developed. The newly developed MIP monolith was produced using TAP as the template molecule, 4-vinylpyridine (4-VP) as the functional monomer. The TAP-MIP monolith synthesized in a micropipette tip could be connected with syringes in different sizes simply to perform SPME process without any other treatment. The derivated MIP monolith showed high selectivity and enrichment ability for TAP. A simple, rapid and sensitive method for the determination of TAP in milk and honey using polymer monolith microextraction (PMME) based on the MIP monolith combined with high-performance liquid chromatography-photodiodes array detector was developed. Several parameters affecting MIP monolith microextraction were investigated, including the flow rate, volume, pH and salt concentration of sample, the type and volume of washing solution, the type and flow rate of eluent. The recovery of this method for TAP was investigated and high recoveries of 92.9-99.3% from milk and honey were obtained with relative standard deviations less than 4.9%.
Authors:
Juan Li; Huaixia Chen; Hui Chen; Yong Ye
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-21
Journal Detail:
Title:  Journal of separation science     Volume:  -     ISSN:  1615-9314     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088554     Medline TA:  J Sep Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan, P. R. China.
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