Document Detail

Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene.
MedLine Citation:
PMID:  5256999     Owner:  NLM     Status:  MEDLINE    
Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.
C Huggins; S Morii; J Pataki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  62     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1969 Mar 
Date Detail:
Created Date:  1969-09-22     Completed Date:  1969-09-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  704-7     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / drug effects*
Benz(a)Anthracenes / administration & dosage,  pharmacology*
Hemorrhage / chemically induced
Injections, Intravenous
Reg. No./Substance:
0/Benz(a)Anthracenes; 0/Emulsions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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