Document Detail

Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene.
MedLine Citation:
PMID:  5256999     Owner:  NLM     Status:  MEDLINE    
Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.
C Huggins; S Morii; J Pataki
Related Documents :
18778859 - Contaminant accumulation and biomarker responses in caged mussels, mytilus galloprovinc...
11924549 - Impact of wildfires on the air quality of mexico city, 1992-1999.
12880069 - Evolution of the magnitude and spatial extent of the weekend ozone effect in california...
20714359 - New era in treatment for phenylketonuria: pharmacologic therapy with sapropterin dihydr...
12322749 - Precipitation scavenging of polychlorinated biphenyls and polycyclic aromatic hydrocarb...
18677989 - Current and future linked responses of ozone and pm2.5 to emission controls.
3228689 - Feeding behavior by parasitic phase lampreys, ichthyomyzon unicuspis.
19923389 - Medium- to long-run implications of high food prices for global nutrition.
7179609 - Crystallisation of calcium oxalate dihydrate in normal urine in presence of sodium copp...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  62     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1969 Mar 
Date Detail:
Created Date:  1969-09-22     Completed Date:  1969-09-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  704-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Glands / drug effects*
Benz(a)Anthracenes / administration & dosage,  pharmacology*
Hemorrhage / chemically induced
Injections, Intravenous
Reg. No./Substance:
0/Benz(a)Anthracenes; 0/Emulsions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relationship of sleep, respiration, and anesthesia in the porpoise: a preliminary report.
Next Document:  Formation of neuromuscular junctions in embryonic cell cultures.