| Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene. | |
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MedLine Citation:
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PMID: 5256999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism. |
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Authors:
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C Huggins; S Morii; J Pataki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 62 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1969 Mar |
Date Detail:
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Created Date: 1969-09-22 Completed Date: 1969-09-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 704-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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drug effects* Animals Benz(a)Anthracenes / administration & dosage, pharmacology* Emulsions Hemorrhage / chemically induced Injections, Intravenous Rats |
| Chemical | |
Reg. No./Substance:
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0/Benz(a)Anthracenes; 0/Emulsions |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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