Document Detail


Selective deficit in antibodies specific for the superantigen binding site of gp120 in HIV infection.
MedLine Citation:
PMID:  9806756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV infection is characterized by accelerated apoptosis and progressive loss of B cells. To see whether these abnormalities are related to the property of gp120 to act as a superantigen for VH3(+) B cells, we probed the temporal development of VH3(+) antibodies in HIV-1-infected subjects over a 7-year period. We found that VH3(+) antibodies specific for the gp120 superantigen binding site are deficient. Since VH3(+) antibodies impart protective responses to infectious agents, we quantified VH3(+) antibodies in serum samples from HIV-seropositive slow progressors and from patients who progressed to AIDS-related manifestations. We found that paucity in VH3(+) antibodies is a marker of rapid clinical decline. Remarkably, anti-gp160 VH3(+) antibodies showed a gradual decrease in progressors and, with time, varied depending on the viral load. We conclude that disease aggravation is associated with a decrease of the magnitude of the humoral response, that VH3(+) antibodies play an important role in protection, and that their underexpression may accelerate disease progression. We propose that vaccine preparations able to trigger VH3(+) antibodies might confer a better protection against HIV infection. This work also represents a novel mechanism of humoral deficiency resulting from the capacity of a viral antigen to affect an important subset of the B cell repertoire and to induce B cell death by apoptosis.
Authors:
L Juompan; P Lambin; M Zouali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  12     ISSN:  0892-6638     ISO Abbreviation:  FASEB J.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-11-25     Completed Date:  1998-11-25     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1473-80     Citation Subset:  IM; X    
Affiliation:
Département d'Immunologie, Institut Pasteur, 75015 Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Binding Sites, Antibody*
Female
HIV Antibodies / biosynthesis,  immunology*
HIV Envelope Protein gp120 / immunology*
HIV Infections / immunology*
HIV-1 / immunology*,  isolation & purification
Humans
Male
Superantigens / immunology
Viral Load
Chemical
Reg. No./Substance:
0/HIV Antibodies; 0/HIV Envelope Protein gp120; 0/Superantigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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