Document Detail

Selective colonization by Helicobacter pylori of the deep gastric glands and intracellular canaliculi of parietal cells in the setting of chronic proton pump inhibitor use.
MedLine Citation:
PMID:  11943964     Owner:  NLM     Status:  MEDLINE    
Colonization by Helicobacter pylori of the acid-secreting tubules of gastric glands and the canaliculi of parietal cells has only rarely been reported. The presence of these organisms in such "deep" locations has only been reported in association with the more typical superficial colonization of the mucous gel layer overlying gastric epithelial cells. We report two cases of deep H. pylori infection without the presence of superficial organisms. Both patients had been using proton pump inhibitors for many years. We review the literature regarding the distribution of H. pylori within the stomach and the effect of proton pump inhibitor use on H. pylori distribution.
Peter P Tagkalidis; Simon G Royce; Finlay A Macrae; Prithi S Bhathal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  14     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-10     Completed Date:  2002-05-15     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-6     Citation Subset:  IM    
Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia.
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MeSH Terms
Benzimidazoles / administration & dosage
Enzyme Inhibitors / administration & dosage
Gastric Mucins / metabolism
Gastric Mucosa / microbiology*
Helicobacter pylori / isolation & purification*
Middle Aged
Omeprazole / administration & dosage
Parietal Cells, Gastric / microbiology*
Proton Pumps / antagonists & inhibitors*
Sulfoxides / administration & dosage
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Benzimidazoles; 0/Enzyme Inhibitors; 0/Gastric Mucins; 0/Proton Pumps; 0/Sulfoxides; 73590-58-6/Omeprazole; D8TST4O562/pantoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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