Document Detail


Selective breeding to develop lines of baboons with high and low blood pressure.
MedLine Citation:
PMID:  8505095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lines of baboons with high and low blood pressure were developed by selective breeding. Blood pressure was measured in 456 adult feral baboons under ketamine immobilization by direct arterial cannulation. Males with blood pressures two standard deviations and females with blood pressures one standard deviation above and below the cumulative mean were selected as progenitors. High males were mated with high females and low males were mated with low females. We measured blood pressure and plasma renin activity on 100 progeny, 54 males and 46 females, greater than 44 months of age with an abbreviated tether protocol and software program for data collection. Mean systolic and diastolic nighttime pressures for the high line were 126/72 and for the low line were 114/65 mm Hg. Line differences for systolic (12 mm Hg) and for diastolic (7 mm Hg) pressures were significant (p < 0.001). The line difference for plasma renin activity (1.1 [ng/mL]/hr) was not significant. Progeny pressures ranged from 84/49 to 191/126 mm Hg. There was no sex effect on blood pressure or plasma renin activity line differences. Heritability of systolic pressure was 0.46 +/- 0.19 and of diastolic pressure was 0.32 +/- 0.19. These results indicate that, by selective breeding and rigorous measurement of blood pressure, lines of baboons with significant difference in blood pressure can be developed.
Authors:
D Carey; C M Kammerer; R E Shade; K S Rice; H C McGill
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  21     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-02     Completed Date:  1993-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1076-9     Citation Subset:  IM    
Affiliation:
Southwest Foundation for Biomedical Research, San Antonio, Tex. 78228.
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MeSH Terms
Descriptor/Qualifier:
Animal Husbandry*
Animals
Blood Pressure*
Circadian Rhythm
Female
Heart Rate
Male
Papio / physiology*
Renin / blood
Grant Support
ID/Acronym/Agency:
HL-45323/HL/NHLBI NIH HHS; HV 53030/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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