| Selective breeding for increased cholinergic function: increased serotonergic sensitivity. | |
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MedLine Citation:
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PMID: 3244712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the serotonergic antagonist cyproheptadine and the agonist 1(m-chlorophenyl) piperazine (mCPP) on core body temperature, locomotor activity and operant responding for a water reward were determined in two lines of Sprague-Dawley rats selectively bred for differences in sensitivity to the anticholinesterase, diisopropyl fluorophosphate (DFP). Both cyproheptadine and mCPP induced a dose-dependent hypothermia that was significantly greater in the line of rat more sensitive to DFP (the Flinders Sensitive Line--FSL). On the other hand, the mild stimulant effects of cyproheptadine on operant responding and locomotor activity were similar in the two lines, whereas the marked inhibitory effects of mCPP on these two measures were significantly greater in the FSL rats. This study also confirmed that the FSL rats were significantly more sensitive to the hypothermic effects of oxotremorine, a muscarinic agonist, and showed that pretreatment with cyproheptadine reduced the hypothermic effects of oxotremorine to a similar extent in the two lines. These findings indicate that rats selectively bred for increased cholinergic function (FSL) also differ in their sensitivity to serotonergic agonists and antagonists, thereby extending the evidence for cholinergic-serotonergic interactions in the rat. |
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Authors:
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E Wallis; D H Overstreet; A D Crocker |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 31 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-06-06 Completed Date: 1989-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 345-50 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, Flinders University of South Australia, Bedford Park. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Body Temperature / drug effects Cyproheptadine / pharmacology* Dose-Response Relationship, Drug Drug Interactions Female Male Motor Activity / drug effects Oxotremorine / pharmacology Piperazines / pharmacology* Rats Rats, Inbred Strains Receptors, Cholinergic / physiology Serotonin / physiology |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 0/Receptors, Cholinergic; 129-03-3/Cyproheptadine; 50-67-9/Serotonin; 6640-24-0/1-(3-chlorophenyl)piperazine; 70-22-4/Oxotremorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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