Document Detail


Selective breeding for ethanol-related traits alters circadian phenotype.
MedLine Citation:
PMID:  23414725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies in mice and rats have shown that selective breeding for high and low ethanol preference results in divergence of circadian phenotype in the selected lines. These results indicate that some alleles influencing ethanol preference also contribute to circadian rhythm regulation. Selective breeding has also been used to produce lines of mice differing in a number of other ethanol-related traits, while studies of phenotypic and genetic correlation indicate that diverse ethanol-related traits are influenced by both shared and unshared genetics. In the present study, we examined several features of circadian activity rhythms in a mouse line selected for binge-like drinking and in mouse lines selected for high and low severity of ethanol withdrawal convulsions. Specifically, Experiment 1 compared High Drinking in the Dark (HDID-1) mice to their genetically heterogeneous progenitor line (HS/Npt), and Experiment 2 compared Withdrawal Seizure-Prone (WSP-2) and Withdrawal Seizure-Resistant (WSR-2) mice. Both line pairs displayed differences in their daily activity patterns under light-dark conditions. In addition, HDID-1 mice showed shorter free-running periods in constant light and less coherent activity rhythms across lighting conditions relative to HS/Npt controls, while WSP-2 mice showed longer free-running periods in constant darkness relative to WSR-2 mice. These results strengthen the evidence for genetic linkages between responsiveness to ethanol and circadian regulation, and extend this evidence to include ethanol-related phenotypes other than preference drinking. However, the present results also indicate that the nature of genetic correlations between and within phenotypic domains is highly complex.
Authors:
Walter D McCulley; Sonja Ascheid; John C Crabbe; Alan M Rosenwasser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-02-13
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  47     ISSN:  1873-6823     ISO Abbreviation:  Alcohol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-03     Completed Date:  2014-01-06     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding / methods*
Circadian Rhythm / drug effects*,  genetics*
Ethanol / administration & dosage*
Male
Mice
Phenotype*
Species Specificity
Grant Support
ID/Acronym/Agency:
AA10760/AA/NIAAA NIH HHS; AA13519/AA/NIAAA NIH HHS; P50 AA010760/AA/NIAAA NIH HHS; R24 AA020245/AA/NIAAA NIH HHS; U01 AA013519/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
3K9958V90M/Ethanol
Comments/Corrections

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