| Selective bowel decontamination does not alter hepatic regeneration in rats. | |
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MedLine Citation:
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PMID: 1551548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to determine whether changes to the gut flora that occur following norfloxacin-induced selective bowel decontamination alter hepatic regenerative activity. Adult rats (n = 6 per group) were treated with norfloxacin (10 mg/day) or vehicle for 10 days before 70% partial hepatectomy. Hepatic regenerative activity was determined 24 hours after surgery by documenting restitution of liver mass, [3H]thymidine incorporation into DNA, and ornithine decarboxylase activity in the liver. The results of the study revealed that hepatic regeneration was unaffected by norfloxacin therapy. Thus, selective bowel decontamination with norfloxacin does not alter hepatic regenerative activity following partial hepatectomy in the rat. |
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Authors:
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E L MacIntosh; T Gauthier; G K Harding; G Y Minuk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 102 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-04-27 Completed Date: 1992-04-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1403-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Manitoba, Winnipeg, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Physiological Phenomena* Intestines / microbiology* Liver Regeneration* Male Norfloxacin / pharmacology Putrescine / physiology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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110-60-1/Putrescine; 70458-96-7/Norfloxacin |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 1992 Dec;103(6):1993-4
[PMID:
1451996
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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