Document Detail

Selective antimicrobial modulation of human microbial flora: infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria.
MedLine Citation:
PMID:  7017019     Owner:  NLM     Status:  MEDLINE    
To reduce the frequency and severity of bacterial infection, selective antimicrobial modulation (SAM) was applied in 39 patients with severely decreased host defense mechanisms. The objective was to eliminate potentially pathogenic aerobic microorganisms with minimal disturbance of the normal anaerobic bacterial flora. Elimination of potentially pathogenic aerobic microorganisms was easily accomplished in patients not infected at hospitalization. The anaerobic flora seemed to be undisturbed, and selection of or overgrowth with resistant microorganisms did not occur. The microbiologic results of the SAM regimen correlated with the incidence of infection. Only three major infections occurred in 23 patients who were free of potentially pathogenic microorganisms; 10 major infections occurred in 16 patients who were not free of potential pathogens. Seven of these 10 infections were present at hospitalization. The incidence of major infections was 47% in the patients on the SAM regimen and 82% in a group of control patients with a similar risk of infection.
H F Guiot; J W van der Meer; R van Furth
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  143     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  644-54     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Aplastic / drug therapy
Anti-Bacterial Agents / therapeutic use*
Bacteria / pathogenicity*
Bacterial Infections / mortality,  prevention & control*
Bone Marrow Transplantation
Feces / microbiology
Leukemia, Myeloid, Acute / drug therapy
Middle Aged
Mouth Diseases / drug therapy
Patient Isolation*
Pharyngitis / drug therapy
Rectal Diseases / drug therapy
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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