Document Detail

Selective anorexigenic effects of corticotropin releasing hormone in the rhesus monkey.
MedLine Citation:
PMID:  1862219     Owner:  NLM     Status:  MEDLINE    
1. Rhesus monkeys were equipped with a novel intracerebroventricular (i.c.v.) cannula system and trained to respond under operant schedules of food presentation or termination of stimuli associated with the delivery of shock (escape). 2. CRH decreased food-maintained behavior in a dose-related manner over the range of (0.3-10 micrograms/kg) but did not affect escape responding, demonstrating a selective effect on food-maintained responding. 3. This selective effect was related to the tendency for responding to stop after delivery of a food pellet when higher doses of CRH were given, consistent with the notion that a conditioned aversion to food was established in the presence of CRH. 4. This may suggest that in hyperaroused clinical states such as depression and anorexia nervosa, focus is shifted away from appetitive tasks as a result of increased levels of CRH.
J R Glowa; J D Bacher; M Herkenham; P W Gold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  379-91     Citation Subset:  IM    
Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD.
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MeSH Terms
Appetite Depressants*
Behavior, Animal / drug effects
Conditioning, Operant / drug effects
Corticotropin-Releasing Hormone / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Injections, Intraventricular
Macaca mulatta
Reinforcement Schedule
Reg. No./Substance:
0/Appetite Depressants; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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