Document Detail


Selective anorexigenic effects of corticotropin releasing hormone in the rhesus monkey.
MedLine Citation:
PMID:  1862219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Rhesus monkeys were equipped with a novel intracerebroventricular (i.c.v.) cannula system and trained to respond under operant schedules of food presentation or termination of stimuli associated with the delivery of shock (escape). 2. CRH decreased food-maintained behavior in a dose-related manner over the range of (0.3-10 micrograms/kg) but did not affect escape responding, demonstrating a selective effect on food-maintained responding. 3. This selective effect was related to the tendency for responding to stop after delivery of a food pellet when higher doses of CRH were given, consistent with the notion that a conditioned aversion to food was established in the presence of CRH. 4. This may suggest that in hyperaroused clinical states such as depression and anorexia nervosa, focus is shifted away from appetitive tasks as a result of increased levels of CRH.
Authors:
J R Glowa; J D Bacher; M Herkenham; P W Gold
Related Documents :
16812349 - Factors affecting choice of signaled or unsignaled food schedules.
1798769 - Serial spatial reversal learning in rats: comparison of instrumental and automaintenanc...
6415749 - Effects of cocaine, chlordiazepoxide, and chlorpromazine on responding of squirrel monk...
15088869 - Effect of upcoming reward type when rats press a lever for ethanol.
17408729 - Individual differences in novelty- and cocaine-induced locomotor activity as predictors...
19853629 - Dopamine d4 receptor (d4r) deletion in mice does not affect operant responding for food...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  379-91     Citation Subset:  IM    
Affiliation:
Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants*
Behavior, Animal / drug effects
Conditioning, Operant / drug effects
Corticotropin-Releasing Hormone / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Food
Injections, Intraventricular
Macaca mulatta
Male
Reinforcement Schedule
Chemical
Reg. No./Substance:
0/Appetite Depressants; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pituitary abnormalities in eating disorders: further evidence from MRI studies.
Next Document:  Ontogeny of phenylalanine (endogenous cholecystokinin) induced modulation of food intake in normal a...