Document Detail


Selective alpha 1-adrenoreceptor blockers in the treatment of hypertension: should we be using them more?
MedLine Citation:
PMID:  1687998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has become apparent in recent years that in the treatment of essential hypertension, reduction of blood pressure alone is not sufficient to reduce significantly the morbidity and mortality from ischaemic heart disease. Since the emergence of a multifactorial approach to the prevention of cardiovascular disease, the potential interaction between antihypertensive therapy and metabolic factors, such as control of blood glucose and lipid levels, has become an important consideration. Abnormal function of the sympathetic nervous system may contribute to both the initiation, or maintenance, of hypertension and the associated metabolic disturbances. The new generation of selective alpha 1-adrenoreceptor blockers, besides lowering blood pressure, appear to have favourable effects on lipid and glucose metabolism. The use of these drugs and their place in the treatment of hypertension are discussed.
Authors:
M Ligueros; R Unwin; M Wilkins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  1     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-08-31     Completed Date:  1992-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / therapeutic use*
Drug Utilization
Humans
Hypertension / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists

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