Document Detail


Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing.
MedLine Citation:
PMID:  22840394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic activation achieved via in vitro optogenetic stimulation of nucleus accumbens, a terminal field of dopaminergic neurons, elicits real-time dopamine release. This mechanism occurs via direct actions on dopamine terminals, does not require changes in neuron firing within the midbrain, and is dependent on glutamatergic receptor activity. More importantly, we demonstrate that in vivo selective activation of cholinergic interneurons is sufficient to elicit dopamine release in the nucleus accumbens. Therefore, the control of accumbal extracellular dopamine levels by endogenous cholinergic activity results from a complex convergence of neurotransmitter/neuromodulator systems that may ultimately synergize to drive motivated behavior.
Authors:
Roger Cachope; Yolanda Mateo; Brian N Mathur; James Irving; Hui-Ling Wang; Marisela Morales; David M Lovinger; Joseph F Cheer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-07-11
Journal Detail:
Title:  Cell reports     Volume:  2     ISSN:  2211-1247     ISO Abbreviation:  Cell Rep     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2013-03-04     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  101573691     Medline TA:  Cell Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholinergic Neurons / drug effects,  metabolism*,  physiology
Dopamine / metabolism*
Dopaminergic Neurons / metabolism
Interneurons / drug effects,  metabolism*,  physiology
Male
Mice
Mice, Transgenic
Models, Biological
Nucleus Accumbens / drug effects,  metabolism*
Receptors, Nicotinic / genetics,  metabolism,  physiology
Reward*
Substrate Specificity
Up-Regulation / drug effects
Grant Support
ID/Acronym/Agency:
DA022340/DA/NIDA NIH HHS; DA025890/DA/NIDA NIH HHS; R01 DA022340/DA/NIDA NIH HHS; R01 DA025890/DA/NIDA NIH HHS; R21 DA033926/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Nicotinic; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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