| Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice. | |
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MedLine Citation:
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PMID: 20953384 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The immunomodulatory activity of an Indian neutraceutical spice, saffron (Crocus sativus) was studied on Th(1) and Th(2) limbs of the immune system. Oral administration of alcoholic extract of Crocus sativus (ACS) at graded dose levels from 1.56-50 mg/kg p.o. potentiated the Th(2) response of humoral immunity causing the significant increases in agglutinating antibody titre in mice at a dose of 6.25 mg/kg and an elevation of CD19(+) B cells and IL-4 cytokine, a signature cytokine of Th(2) pathway. Appreciable elevation in levels of IgG-1 and IgM antibodies of the primary and secondary immune response was observed. However, ACS showed no appreciable expression of the Th(1) cytokines IL-2 (growth factor for CD4(+) T cells) and IFN-γ (signature cytokine of Th(1) response). A significant modulation of immune reactivity was observed in all the animal models used. This paper represents the selective upregulation of the Th(2) response of the test material and suggests its use for subsequent selective Th(2) immunomodulation. |
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Authors:
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Sarang Bani; Anjali Pandey; Vijai K Agnihotri; Vijaylata Pathania; Bikram Singh |
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Publication Detail:
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Type: Journal Article Date: 2010-09-13 |
Journal Detail:
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Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2011 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2011 |
Date Detail:
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Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Cell Biology (Flowcytometry), Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi 180001, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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