Document Detail


Selective serotonin reuptake inhibitor and bleeding in a cynomolgus macaque (Macaca fascicularis).
MedLine Citation:
PMID:  24956214     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Selective serotonin reuptake inhibitors (SSRI) are associated with an increased bleeding risk in humans. This report describes a bleeding event in a cynomolgus macaque (Macaca fascicularis) treated with the SSRI sertraline HCl (Zoloft). During the treatment course, the subject presented with a maculopapular rash, cutaneous bleeding, epistaxis, bleeding from the eye, melena, and a severe thrombocytopenia. To our knowledge, this report is the first description of an SSRI-related adverse event in a nonhuman primate. This report demonstrates that the clinical presentation of SSRI-associated bleeding in cynomolgus macaques is consistent with that reported in humans and that complications from SSRI treatment should be considered as a differential diagnosis for maculopapular dermatitis or spontaneous bleeding in this species.
Authors:
Marnie G Silverstein; Colette Kirk El-Amin; Carol A Shively
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Comparative medicine     Volume:  64     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-24     Completed Date:  -     Revised Date:  2014-12-01    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R0IHL87103//PHS HHS; R21MH086731/MH/NIMH NIH HHS; T32 OD 010957/OD/NIH HHS

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