Document Detail

Selective estrogen receptor modulator promotes weight loss in ovariectomized female rhesus monkeys (Macaca mulatta) by decreasing food intake and increasing activity.
MedLine Citation:
PMID:  22252940     Owner:  NLM     Status:  MEDLINE    
The effect of hormone replacement therapy (HRT) on body weight in postmenopausal women is controversial, with studies reporting an increase, a decrease, and no change in body weight. To examine estrogen receptor actions on body weight, we investigated the effects of treatment with a selective estrogen receptor modulator (SERM) on body weight, food intake, and activity and metabolic rate in a nonhuman primate model. Eighteen ovariectomized female rhesus monkeys were treated with a nonsteroidal SERM (GSK232802A, 5 mg/kg po) for 3 mo. GSK232802A decreased lutenizing hormone (P < 0.0001) and follicle-stimulating hormone levels (P < 0.0001), consistent with the estrogenic action of the compound. GSK232802A treatment produced a small but sustained weight loss (4.6 ± 1.0%, P < 0.0001) and reduced adiposity (P < 0.0001), which was due at least in part to a suppression of food intake (3.6 ± 3.7%, P < 0.0001). Physical activity increased during the 3rd mo of treatment (P = 0.04). Baseline activity level and the change in activity due to treatment were correlated, with the most sedentary individuals exhibiting increased physical activity during the 1st mo of treatment (P = 0.02). Metabolic rate did not change (P = 0.58). These results indicate that GSK232802A treatment reduces body weight and adiposity in ovariectomized nonhuman primates by suppressing food intake and increasing activity, particularly in the most sedentary individuals. These findings suggest that SERM treatment may counteract weight gain in postmenopausal women.
Elinor L Sullivan; Jean Shearin; Frank H Koegler; Judy L Cameron
Publication Detail:
Type:  Journal Article     Date:  2012-01-17
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  302     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-17     Revised Date:  2012-08-30    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E759-67     Citation Subset:  IM    
Division of Reproductive Sciences and Neuroscience, Oregon National Primate Research Center, Beaverton, USA.
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MeSH Terms
Alkaline Phosphatase / blood
Body Composition / drug effects
Body Fat Distribution
Body Weight / drug effects
Eating / drug effects*
Energy Metabolism / drug effects
Leptin / blood
Luteinizing Hormone / blood
Macaca mulatta
Motor Activity / drug effects*
Selective Estrogen Receptor Modulators / pharmacology*
Triiodothyronine / blood
Weight Loss / drug effects*
Reg. No./Substance:
0/Leptin; 0/Selective Estrogen Receptor Modulators; 6893-02-3/Triiodothyronine; 9002-67-9/Luteinizing Hormone; EC Phosphatase

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