Document Detail


Selective esterifications of primary alcohols in a water-containing solvent.
MedLine Citation:
PMID:  22937741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO(3), and Oxyma or Oxyma derivative 5b in 5% H(2)O-CH(3)CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.
Authors:
Yong Wang; Bilal A Aleiwi; Qinghui Wang; Michio Kurosu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-31
Journal Detail:
Title:  Organic letters     Volume:  14     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2013-01-11     Revised Date:  2014-08-12    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4910-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetates / chemistry*
Alcohols / chemistry*
Esterification
Molecular Structure
Oximes / chemistry*
Solvents
Water / chemistry*
Grant Support
ID/Acronym/Agency:
AI AI084411/AI/NIAID NIH HHS; R01 AI084411/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Acetates; 0/Alcohols; 0/Oximes; 0/Solvents; 0/ethyl 2-cyano-2-(hydroxyimino)acetate; 059QF0KO0R/Water
Comments/Corrections

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