Document Detail

Selective D2-40 lymphatic endothelium immunoreactivity in developing human fetal skin appendages.
MedLine Citation:
PMID:  19725270     Owner:  NLM     Status:  MEDLINE    
D2-40 is a novel monoclonal antibody that recognizes a 40,000 Da O-linked sialoglycoprotein podoplanin. Although its use is becoming more common, little work has been done with human foetuses. We initiated an evaluation of D2-40 antibody immunoreactivity in developing cutaneous adnexa of human fetuses at various gestational ages. Starting from a retrospective cohort of 1,098 human fetal autopsies we identified and selected a total of 48 fetuses ranging from the 12th week gestational age to term appropriate for this study. We demonstrated that the gems of the hair follicles were D2-40 negative in fetuses from the 12th to 15th week gestation, positive in fetuses between the 16th and 20th week of gestation, negative in fetuses from the 21st week gestation to term. Normal adult controls were also negative. This is the first report to demonstrate intense D2-40 immunoreactivity in the gems of hair follicles of developing human skin.
C Bellin; E Fulcheri; M Rutigliani; F Boccardo; C Campisi; T Bellini; E Bonioli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lymphology     Volume:  42     ISSN:  0024-7766     ISO Abbreviation:  Lymphology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-09-03     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155112     Medline TA:  Lymphology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
Department of Pediatrics, S. Martino Hospital, Genova, Italy.
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MeSH Terms
Antibodies, Monoclonal / immunology*
Cohort Studies
Endothelium, Lymphatic / cytology,  metabolism*
Fetus / metabolism*
Gestational Age
Hair Follicle / cytology,  metabolism*
Membrane Glycoproteins
Retrospective Studies
Skin / cytology,  metabolism*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Membrane Glycoproteins; 0/PDPN protein, human; 0/monoclonal antibody D2-40

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