Document Detail


A selective and convenient method for the synthesis of 2-phenylaminothiazolines.
MedLine Citation:
PMID:  21038925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N'-phenylthioureas under mild reaction conditions using either thio-CDI (1,1'-thiocarbonyldiimidazole) or CDI (1,1'-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cyclization products in good yield with excellent selectivity. The scope and selectivity of this methodology are also described.
Authors:
April L Bernacki; Lingyang Zhu; D David Hennings
Related Documents :
21618545 - Effects of lard on the formation of volatiles from the maillard reaction of cysteine wi...
10891135 - Palladium-catalyzed cross-benzannulation of aminoenynes with diynes. highly regioselect...
20703385 - Recent advances in carbocupration of α-heterosubstituted alkynes.
19153975 - Ruthenium-catalyzed synthesis of functionalized dienes from propargylic esters: formal ...
23339655 - Total synthesis of (-)-isoavenaciolide.
20607485 - Triazenoindazoles and triazenopyrazolopyridines: design, synthesis, and cytotoxic activ...
Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5526-9     Citation Subset:  IM    
Affiliation:
Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, USA. april.bernacki@arraybiopharma.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cyclization
Molecular Structure
Thiazoles / chemical synthesis*
Chemical
Reg. No./Substance:
0/Thiazoles; 1779-81-3/2-aminothiazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for contr...
Next Document:  Bisphenol A (BPA) in U.S. food.