Document Detail

A selective and convenient method for the synthesis of 2-phenylaminothiazolines.
MedLine Citation:
PMID:  21038925     Owner:  NLM     Status:  MEDLINE    
A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N'-phenylthioureas under mild reaction conditions using either thio-CDI (1,1'-thiocarbonyldiimidazole) or CDI (1,1'-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cyclization products in good yield with excellent selectivity. The scope and selectivity of this methodology are also described.
April L Bernacki; Lingyang Zhu; D David Hennings
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Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5526-9     Citation Subset:  IM    
Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, USA.
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MeSH Terms
Molecular Structure
Thiazoles / chemical synthesis*
Reg. No./Substance:
0/Thiazoles; 1779-81-3/2-aminothiazoline

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