| A selective and convenient method for the synthesis of 2-phenylaminothiazolines. | |
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MedLine Citation:
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PMID: 21038925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N'-phenylthioureas under mild reaction conditions using either thio-CDI (1,1'-thiocarbonyldiimidazole) or CDI (1,1'-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cyclization products in good yield with excellent selectivity. The scope and selectivity of this methodology are also described. |
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Authors:
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April L Bernacki; Lingyang Zhu; D David Hennings |
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Publication Detail:
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Type: Journal Article Date: 2010-11-01 |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 5526-9 Citation Subset: IM |
Affiliation:
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Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, USA. april.bernacki@arraybiopharma.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyclization Molecular Structure Thiazoles / chemical synthesis* |
| Chemical | |
Reg. No./Substance:
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0/Thiazoles; 1779-81-3/2-aminothiazoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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