Document Detail


Selective COX-2 inhibition reduces leukocyte sticking and improves the microcirculation in TNBS colitis.
MedLine Citation:
PMID:  16614986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of cyclooxygenase-2 inhibitors in the course of experimental colitis is controversially discussed. The aim of this study was to evaluate leukocyte-endothelium interaction and colitis activity after applying the selective cyclooxygenase-2 inhibitor NS-398 in a rat trinitrobenzene sulfonic acid (TNBS) colitis model. The acute phase of TNBS colitis is characterized by a significant reduction of capillary blood flow, capillary density, diuresis, and weight and a significant increase in capillary permeability, leukocyte sticking, and hematocrit. Applying the selective cyclooxygenase-2 inhibitor NS-398 leads to a significant improvement of all microcirculatory parameters and clinical findings compared to the (untreated) colitis group. There are no histopathological differences between the individual colitis groups. Acute colitis is characterized by an extensive disturbance of microcirculation together with signs of systemic inflammatory response syndrome. These alterations are significantly improved by inhibiting cyclooxygenase-2. The results support the described correlation between cyclooxygenase activation and leukocyte-endothelium interaction. Moreover, they underscore the postulated relation between leukocyte-endothelium interaction and capillary blood flow.
Authors:
Martin Kruschewski; Tanja Anderson; Heinz J Buhr; Christoph Loddenkemper
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  51     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-14     Completed Date:  2006-05-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  662-70     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. martin.kruschewski@charite.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Colitis / drug therapy*,  pathology
Colon / blood supply*
Cyclooxygenase 2 Inhibitors / pharmacology*
Disease Models, Animal
Immunohistochemistry
Intestinal Mucosa / blood supply,  pathology
Leukocytes / cytology*,  drug effects
Male
Microcirculation / drug effects,  physiology
Nitrobenzenes / pharmacology*
Probability
Random Allocation
Rats
Rats, Sprague-Dawley
Reference Values
Regional Blood Flow
Sensitivity and Specificity
Sulfonamides / pharmacology*
Tissue Adhesions
Trinitrobenzenesulfonic Acid
Chemical
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Nitrobenzenes; 0/Sulfonamides; 123653-11-2/N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; 2508-19-2/Trinitrobenzenesulfonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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