| Selective C-4 alkylation of pyridine by nickel/Lewis acid catalysis. | |
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MedLine Citation:
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PMID: 20822182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. A variety of substituents on both alkenes and pyridine are tolerated to give linear 4-alkylpyridines in modest to good yields. The addition across styrene, on the other hand, gives branched 4-alkylpyridines. A single example of C-4-selective alkenylation is also described. |
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Authors:
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Yoshiaki Nakao; Yuuya Yamada; Natsuko Kashihara; Tamejiro Hiyama |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 132 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 13666-8 Citation Subset: IM |
Affiliation:
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Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. yoshiakinakao@npc05.mbox.media.kyoto-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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chemistry* Alkenes / chemistry Alkylation Alkynes / chemistry Catalysis Ligands Molecular Structure Nickel / chemistry* Organometallic Compounds / chemistry* Pyridines / chemical synthesis*, chemistry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Alkenes; 0/Alkynes; 0/Ligands; 0/Organometallic Compounds; 0/Pyridines; 7440-02-0/Nickel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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