Document Detail

Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment.
MedLine Citation:
PMID:  23314110     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: : Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice, aiming to distinguish the role of different types of anesthesia in cognitive impairment.
METHODS: : Six- and 60-day-old mice were exposed to various anesthesia regimens. The authors then determined the effects of the anesthesia on learning and memory function, levels of proinflammatory cytokine interleukin-6 and tumor necrosis factor-α in brain tissues, and the amount of ionized calcium-binding adaptor molecule 1-positive cells, the marker of microglia activation, in the hippocampus.
RESULTS: : In this article, the authors show that anesthesia with 3% sevoflurane for 2 h daily for 3 days induced cognitive impairment and neuroinflammation (e.g., increased interleukin-6 levels, 151 ± 2.3% [mean ± SD] vs. 100 ± 9.0%, P = 0.035, n = 6) in young but not in adult mice. Anesthesia with 3% sevoflurane for 2 h daily for 1 day and 9% desflurane for 2 h daily for 3 days induced neither cognitive impairment nor neuroinflammation. Finally, an enriched environment and antiinflammatory treatment (ketorolac) ameliorated the sevoflurane-induced cognitive impairment.
CONCLUSIONS: : Anesthesia-induced cognitive impairment may depend on developmental stage, anesthetic agent, and number of exposures. These findings also suggest the cellular basis and the potential prevention and treatment strategies for anesthesia-induced cognitive impairment, which may ultimately lead to safer anesthesia care and better postoperative outcomes for children.
Xia Shen; Yuanlin Dong; Zhipeng Xu; Hui Wang; Changhong Miao; Sulpicio G Soriano; Dandan Sun; Mark G Baxter; Yiying Zhang; Zhongcong Xie
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  118     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-19     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502-15     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Anesthetics, Inhalation / administration & dosage,  adverse effects*
Brain / drug effects,  growth & development*,  metabolism*
Cognition Disorders / chemically induced,  metabolism*
Drug Therapy, Combination / adverse effects
Encephalitis / chemically induced,  metabolism*
Inflammation Mediators / metabolism*
Isoflurane / administration & dosage,  analogs & derivatives
Maze Learning / drug effects,  physiology
Methyl Ethers / administration & dosage,  adverse effects
Mice, Inbred C57BL
Grant Support
R01 AG041274/AG/NIA NIH HHS; R01 AG041274/AG/NIA NIH HHS; R01 GM088801/GM/NIGMS NIH HHS; R01 GM088801/GM/NIGMS NIH HHS; R21 AG029856/AG/NIA NIH HHS; R21 AG038994/AG/NIA NIH HHS; R21AG029856/AG/NIA NIH HHS; R21AG038994/AG/NIA NIH HHS
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Inflammation Mediators; 0/Methyl Ethers; 28523-86-6/sevoflurane; 57041-67-5/desflurane; CYS9AKD70P/Isoflurane

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