| Selective 5-HT1A receptor agonist, 8-OH-DPAT, locally administered into the dorsal raphe nucleus increased extracellular acetylcholine concentrations in the medial prefrontal cortex of conscious rats. | |
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MedLine Citation:
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PMID: 11769569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a selective 5-hydroxytryptamine (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), directly administered into the dorsal raphe nucleus (DR) on acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) of freely moving rats were investigated by using a microdialysis technique. 8-OH-DPAT (1.0 and 5.0 micrograms) administered into DR significantly increased extracellular ACh concentrations in mPFC in a dose-dependent manner with a maximal increase to 215% and 237% of basal level, respectively, whereas a 0.1 microgram dose of this drug failed to exert such an increase. The present study suggests that the stimulation of somatodendritic 5-HT1A autoreceptors in DR is involved in an enhancement in ACh release in mPFC. |
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Authors:
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H Katsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Volume: 21 ISSN: 1340-2544 ISO Abbreviation: Nihon Shinkei Seishin Yakurigaku Zasshi Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-12-24 Completed Date: 2002-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9509023 Medline TA: Nihon Shinkei Seishin Yakurigaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 121-3 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105-8461 Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Hydroxy-2-(di-n-propylamino)tetralin
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pharmacokinetics* Acetylcholine / analysis* Animals Male Microdialysis Prefrontal Cortex / chemistry* Raphe Nuclei / drug effects* Rats Rats, Wistar Serotonin Agonists / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Agonists; 51-84-3/Acetylcholine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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