Document Detail

Selective 5-HT1A receptor agonist, 8-OH-DPAT, locally administered into the dorsal raphe nucleus increased extracellular acetylcholine concentrations in the medial prefrontal cortex of conscious rats.
MedLine Citation:
PMID:  11769569     Owner:  NLM     Status:  MEDLINE    
The effects of a selective 5-hydroxytryptamine (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), directly administered into the dorsal raphe nucleus (DR) on acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) of freely moving rats were investigated by using a microdialysis technique. 8-OH-DPAT (1.0 and 5.0 micrograms) administered into DR significantly increased extracellular ACh concentrations in mPFC in a dose-dependent manner with a maximal increase to 215% and 237% of basal level, respectively, whereas a 0.1 microgram dose of this drug failed to exert such an increase. The present study suggests that the stimulation of somatodendritic 5-HT1A autoreceptors in DR is involved in an enhancement in ACh release in mPFC.
H Katsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology     Volume:  21     ISSN:  1340-2544     ISO Abbreviation:  Nihon Shinkei Seishin Yakurigaku Zasshi     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-12-24     Completed Date:  2002-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509023     Medline TA:  Nihon Shinkei Seishin Yakurigaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  121-3     Citation Subset:  IM    
Department of Psychiatry, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105-8461 Japan.
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MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacokinetics*
Acetylcholine / analysis*
Prefrontal Cortex / chemistry*
Raphe Nuclei / drug effects*
Rats, Wistar
Serotonin Agonists / pharmacology*
Reg. No./Substance:
0/Serotonin Agonists; 51-84-3/Acetylcholine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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