Document Detail


Selection of spirometric measurements in a clinical trial, the Lung Health Study.
MedLine Citation:
PMID:  7881655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although current recommendations for spirometry require that the largest value of FEV1 and FVC should be taken from the largest values of different maneuvers, the validity of this approach was recently questioned. It has been suggested that selection of the maneuver with the largest peak flow or the maneuver with the largest FVC should be used for measurement of spirometric indices. The present analysis was therefore undertaken to determine which method of selection of spirometric maneuvers would give the least short-term variability in a clinical trial population. We examined the spirometry test sessions from 5,885 individuals with mild to moderate chronic airflow obstruction who were screened at two visits 24.9 +/- 17.1 d apart for entry into a multi-center clinical trial, the Lung Health Study. We compared eight potential selection methods for FEV1 and FVC. Using these different selection methods, the coefficient of variation ranged from 4.1 to 4.9% for FEV1 and from 3.5 to 5.7% for FVC. The average absolute difference between the two test sessions ranged from 110 to 123 ml for FEV1 and from 149 to 200 ml for FVC. Although all of the methods gave good results, the mean of the three highest values and the largest single value from all maneuvers provided the least short-term variability for both FEV1 and FVC. We therefore conclude that there is no reason to change the currently recommended selection methods for FEV1 and FVC.
Authors:
R A Wise; J Connett; K Kurnow; J Grill; L Johnson; R Kanner; P Enright
Related Documents :
11297895 - Role of modelling and simulation in phase i drug development.
10709805 - Conditional and exact tests in crossover trials.
1588355 - Application of a stopping rule based on total treatment failures: the postoperative cro...
6597135 - Statistical methodology for clinical trials of caries prophylactic agents--current know...
21384955 - Coarse-graining errors and numerical optimization using a relative entropy framework.
22295015 - Erratum.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  151     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-07     Completed Date:  1995-04-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  675-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Female
Forced Expiratory Volume
Humans
Ipratropium / administration & dosage
Lung Diseases, Obstructive / diagnosis*,  drug therapy,  prevention & control
Male
Middle Aged
Reproducibility of Results
Smoking Cessation
Spirometry / standards*,  statistics & numerical data
Vital Capacity
Grant Support
ID/Acronym/Agency:
M01-RR00064/RR/NCRR NIH HHS; N01-HR46016/HR/NHLBI NIH HHS
Chemical
Reg. No./Substance:
60205-81-4/Ipratropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults.
Next Document:  The familial aggregation of obstructive sleep apnea.