Document Detail


Selection of pulmonary CD4-, CD8-, alpha beta+ T cells expressing V beta 8 T cell receptors.
MedLine Citation:
PMID:  8292384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The double negative (CD4-CD8-) alpha beta+ T cells constitute about 20% of all alpha beta+ T cells in murine lungs. We find that in BALB/c mice 60% of the double negative alpha beta+ pulmonary T cells express receptors of the V beta 8 family whereas only 33% of single positive (CD4+/CD8+) pulmonary T cells express V beta 8. However, in C57BL/6 mice, equal frequencies (25%) of double negative and single positive alpha beta+ pulmonary T cells express V beta 8. The high frequency of double negative V beta 8+ pulmonary T cells is dominantly inherited in (C57BL/6 X BALB/c) F1 offsprings. Further studies exclude the involvement of classic MHC region genes in determining the level of V beta 8 usage among double negative pulmonary T cells. Upon exposure to mycobacterial antigens, double negative alpha beta+ pulmonary T cells are co-enriched in vitro in parallel with gamma delta+ T cells.
Authors:
R Rajasekar; A Augustin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory cell and molecular biology     Volume:  10     ISSN:  1044-1549     ISO Abbreviation:  Am. J. Respir. Cell Mol. Biol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-02-25     Completed Date:  1994-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8917225     Medline TA:  Am J Respir Cell Mol Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
Affiliation:
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Bacterial / immunology
Antigens, CD4 / metabolism*
Antigens, CD8 / metabolism*
Cells, Cultured
Lung / cytology,  immunology*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mycobacterium / immunology
Receptors, Antigen, T-Cell, alpha-beta / biosynthesis*,  genetics
T-Lymphocyte Subsets / immunology*
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, CD4; 0/Antigens, CD8; 0/Receptors, Antigen, T-Cell, alpha-beta

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