| Selection of optimal therapy for neuroblastoma: a study of the immunomodulatory effects of surgery and irradiation in the murine C1300 neuroblastoma model. | |
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MedLine Citation:
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PMID: 2949117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human neuroblastoma is an immunogenic tumor for which therapy directed in an immunologic context may offer some advantage over conventional treatment. This study examines the immunomodulatory effects of surgery and irradiation in the murine C1300 neuroblastoma model. In vivo studies of primary tumor growth characteristics after treatment demonstrated no superiority of either therapeutic modality in control of local tumor or prolongation of host survival. However, irradiated hosts showed an increased ability to reject a secondary tumor challenge, compared to their surgical counterparts. That this phenomenon may be immune-related is suggested by in vitro studies of T lymphocyte function utilizing mixed lymphocyte-tumor cell cultures and PHA lymphoblastogenesis. |
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Authors:
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S L Topalian; M M Ziegler |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of surgical oncology Volume: 34 ISSN: 0022-4790 ISO Abbreviation: J Surg Oncol Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-19 Completed Date: 1987-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 120-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / radiation effects Cell Line Disease Models, Animal Graft Rejection Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes / drug effects, radiation effects* Male Mice Mice, Inbred Strains Mitogens / pharmacology Neoplasm Recurrence, Local Neuroblastoma / immunology*, radiotherapy, surgery Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Mitogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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