| Selection of optimal quantity of hydroxyethyl starch in the cardiopulmonary bypass prime. | |
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MedLine Citation:
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PMID: 15072254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ringer's solution prime reduces colloid osmotic pressure and causes edema during cardiopulmonary bypass, while hydroxyethyl starch (HES) can be used to attenuate this effect. Fifty patients were classified into five equal groups: Group I (preoperative patients) is the control group and the other four groups (II, III, IV, V) received different volume ratios of Ringer's solution to HES (1:0, 2:1, 1:2, 0:1, respectively). This study was aimed at evaluating the optimal quantity of HES regarding body fluids expansion, ventilation and recovery time, blood rheologic properties, clotting parameters, platelet counts, blood loss and red blood cell membrane properties. The results showed a reduction in interstitial fluid (ISF) expansion, changes in blood rheologic properties with the increase in HES quantity and shorter ventilation and recovery times in Groups IV and V. We concluded that the optimal HES quantity in the prime is two thirds, which insures an 85% reduction of ISF relative to Group II, shorter ventilation and recovery times and avoidance of the hazards of high levels of HES. |
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Authors:
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Maha A Ali; Mohamed Saleh |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Perfusion Volume: 19 ISSN: 0267-6591 ISO Abbreviation: Perfusion Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-04-09 Completed Date: 2004-10-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 41-5 Citation Subset: IM |
Affiliation:
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Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt. maha_a_ali@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Loss, Surgical Blood Viscosity / drug effects Body Fluids / metabolism Cardiopulmonary Bypass / adverse effects Dose-Response Relationship, Drug Drug Combinations Edema / etiology Extracellular Fluid / metabolism Female Hetastarch / administration & dosage* Humans Isotonic Solutions / administration & dosage Male Middle Aged Plasma Substitutes / administration & dosage* Respiration, Artificial Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Isotonic Solutions; 0/Plasma Substitutes; 8026-10-6/Ringer's solution; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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