Document Detail


Selection of optimal quantity of hydroxyethyl starch in the cardiopulmonary bypass prime.
MedLine Citation:
PMID:  15072254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ringer's solution prime reduces colloid osmotic pressure and causes edema during cardiopulmonary bypass, while hydroxyethyl starch (HES) can be used to attenuate this effect. Fifty patients were classified into five equal groups: Group I (preoperative patients) is the control group and the other four groups (II, III, IV, V) received different volume ratios of Ringer's solution to HES (1:0, 2:1, 1:2, 0:1, respectively). This study was aimed at evaluating the optimal quantity of HES regarding body fluids expansion, ventilation and recovery time, blood rheologic properties, clotting parameters, platelet counts, blood loss and red blood cell membrane properties. The results showed a reduction in interstitial fluid (ISF) expansion, changes in blood rheologic properties with the increase in HES quantity and shorter ventilation and recovery times in Groups IV and V. We concluded that the optimal HES quantity in the prime is two thirds, which insures an 85% reduction of ISF relative to Group II, shorter ventilation and recovery times and avoidance of the hazards of high levels of HES.
Authors:
Maha A Ali; Mohamed Saleh
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Perfusion     Volume:  19     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-04-09     Completed Date:  2004-10-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt. maha_a_ali@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Loss, Surgical
Blood Viscosity / drug effects
Body Fluids / metabolism
Cardiopulmonary Bypass / adverse effects
Dose-Response Relationship, Drug
Drug Combinations
Edema / etiology
Extracellular Fluid / metabolism
Female
Hetastarch / administration & dosage*
Humans
Isotonic Solutions / administration & dosage
Male
Middle Aged
Plasma Substitutes / administration & dosage*
Respiration, Artificial
Time Factors
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Isotonic Solutions; 0/Plasma Substitutes; 8026-10-6/Ringer's solution; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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