| Selection for intrinsic endurance modifies endocrine stress responsiveness. | |
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MedLine Citation:
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PMID: 20682296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical exercise dampens an individual's stress response and decreases symptoms of anxiety and depression disorders. While the extrinsic relationship of exercise and psychological state is established, their intrinsic relationship is unresolved. We investigated the potential intrinsic relationship of exercise with stress responsiveness using NIH rats bidirectionally selected for intrinsic endurance capacity. Selection resulted in two populations, one with high intrinsic endurance (high capacity runners; HCR) and one with low intrinsic endurance (low capacity runners; LCR). Animals from these populations were subjected to the elevated plus maze (EPM) and novel environment to assess levels of anxiety-like behavior, and to restraint stress to determine stress responsiveness. Pre-test plasma corticosterone levels and the response of plasma corticosterone to exposure to the EPM and restraint were analyzed using ELISA. A dexamethasone suppression test was performed to assess negative feedback tone of corticosterone release. Pre-test plasma corticosterone levels were similar between LCR and HCR, and these populations had similar behavioral and corticosterone responses to the EPM. Following restraint, HCR animals exhibited more anxiotypic behavior than LCR animals on the EPM, and exhibited an increase in plasma corticosterone following EPM and restraint that was not observed in LCR animals. HCR animals also exhibited more anxiotypic behavior in the novel environment compared to LCR animals. Plasma corticosterone levels were equally reduced in both populations following dexamethasone administration. Overall, our data suggest a positive genetic relationship between exercise endurance and stress responsiveness, which is at odds with the established extrinsic relationship of these traits. |
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Authors:
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R Parrish Waters; Kenneth J Renner; Cliff H Summers; Michael J Watt; Gina L Forster; Lauren G Koch; Steven L Britton; John G Swallow |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-08-02 |
Journal Detail:
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Title: Brain research Volume: 1357 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-14 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 53-61 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Department of Neurosciences, The Medical University of South Carolina, Charleston, SC 29425, USA. watersrp@musc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Anxiety / blood, physiopathology Behavior, Animal / physiology Breeding Corticosterone / blood* Enzyme-Linked Immunosorbent Assay Female Hypothalamo-Hypophyseal System / physiopathology* Male Physical Endurance / physiology* Pituitary-Adrenal System / physiopathology* Rats Restraint, Physical Stress, Physiological / physiology* Stress, Psychological / blood, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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HL6427/HL/NHLBI NIH HHS; P20 RR15567/RR/NCRR NIH HHS; R24 RR017718-01/RR/NCRR NIH HHS; R24 RR017718-10/RR/NCRR NIH HHS; RR17718/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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