| Selection of disease-specific biomarkers by integrating inflammatory mediators with clinical informatics in AECOPD patients: a preliminary study. | |
| | |
MedLine Citation:
|
PMID: 21883889 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Systemic inflammation is a major factor influencing the outcome and quality of patient with chronic obstructive pulmonary disease (COPD) and acute exacerbations (AECOPD). Due to the inflammatory complexity, a great challenge is still confronted to optimize the identification and validation of disease-specific biomarkers. The present study aimed at developing a new protocol of specific biomarker evaluation by integrating proteomic profiles of inflammatory mediators with clinical informatics in AECOPD patients, understand better their function and signal networks. Methods: Plasma samples were collected from healthy non-smokers or patients with stable COPD (sCOPD) or AECOPD on days 1 and 3 of the admission and discharging day (day 7-10). Fouty chemokines were measured using a chemokine multiplex antibody array. Clinical informatics was achieved by a Digital Evaluation Score System (DESS) for assessing severity of patients. Chemokine data was compared among different groups and its correlation with DESS scores was performed by SPSS software. Results: Of 40 chemokines, 30 showed significant difference between sCOPD patients and healthy controls, 16 between AECOPD patients and controls, and 13 between AECOPD patients and both sCOPD and controls, including BTC, IL-9,IL-18Bpa, CCL22,CCL23, CCL25, CCL28, CTACK, LIGHT, MSPa, MCP-3, MCP-4 and OPN. Of them, some had significant correlation with DESS scores. Conclusion: There is a disease-specific profile of inflammatory mediators in COPD and AECOPD patients which may have a potential diagnostics together with clinical informatics of patients. Our preliminary study suggested that integration of proteomics with clinical informatics can be a new way to validate and optimize disease-special biomarkers. |
| | |
Authors:
|
Hong Chen; Zhenju Song; Mengjia Qian; Chunxue Bai; Xiangdong Wang |
Related Documents
:
|
20199199 - Eeg evidence of posterior cortical disconnection in pd and related dementias. 9159739 - Mitochondrial respiratory chain function in multiple system atrophy. 21567189 - Double-contrast barium enteroclysis as a patency tool for nonsteroidal anti-inflammator... 17426909 - Apathy and verbal fluency in stn-stimulated pd patients. an observational follow-up study. 9247979 - Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder pat... 8848209 - S-methylation in parkinson's disease. 9692519 - Kartagener's syndrome: a re-visit with chinese perspectives. 2941289 - Use of ciprofloxacin in the treatment of pseudomonas aeruginosa infections. 19490619 - Reduced complexity of activity patterns in patients with chronic fatigue syndrome: a ca... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-25 |
Journal Detail:
|
Title: Journal of cellular and molecular medicine Volume: - ISSN: 1582-4934 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101083777 Medline TA: J Cell Mol Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. |
Affiliation:
|
Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China Emergency Department, Zhongshan Hospital, Fudan University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastr...
Next Document: Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype.