Document Detail


Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity.
MedLine Citation:
PMID:  18304593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A positive genetic relationship between aerobic capacity and voluntary exercise has been suggested from earlier studies of mice selected for increased wheel-running activity. To further investigate the relationship between aerobic capacity and exercise behavior, wheel-running activity was studied in female rats bidirectionally selected for intrinsic aerobic capacity (high capacity runners - HCR; low capacity runners - LCR). Aerobic capacity was measured using a forced treadmill paradigm; the subpopulations of animals used in this experiment exhibited a 471% difference in endurance capacity. Rats were housed individually, with or without access to running wheels. Wheel-running activity was recorded and analyzed from weeks two through seven during an eight-week trial to determine voluntary activity levels. HCR animals exhibited 33% greater total wheel-running distance per day compared to LCR rats (16,838.7+1337.30 m versus 12,665.8+893.88 m), which was due to the HCR rats exhibiting increases in both running speed and duration over LCR rats. Differences in the intermittency of wheel running were also observed. HCR rats engaged in more bouts of running per day than LCR rats, and trended towards running faster, for more time, and for longer distances during bouts of running than LCR rats. Following the running trial, measurement of plasma corticosterone concentration and striatal dopaminergic activity showed differences between HCR and LCR rats, suggesting a divergence of physiological systems that could potentially influence locomotor behaviors in these lines. These results are consistent with earlier work, and suggest an evolutionarily conserved relationship between physiological capacity and behavioral activity of exercise.
Authors:
R P Waters; K J Renner; R B Pringle; Cliff H Summers; S L Britton; L G Koch; J G Swallow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-01-26
Journal Detail:
Title:  Physiology & behavior     Volume:  93     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-07-31     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1044-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal
Biogenic Monoamines / metabolism*
Body Mass Index
Corticosterone / blood*
Movement / physiology*
Physical Conditioning, Animal / methods*
Rats
Selection, Genetic*
Grant Support
ID/Acronym/Agency:
HL6427/HL/NHLBI NIH HHS; NIH P20 RR15567/RR/NCRR NIH HHS; P20 RR015567-01/RR/NCRR NIH HHS; R01 HL064270/HL/NHLBI NIH HHS; R01 HL064270-01/HL/NHLBI NIH HHS; R24 RR017718/RR/NCRR NIH HHS; R24 RR017718-01/RR/NCRR NIH HHS; RR17718/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; W980KJ009P/Corticosterone
Comments/Corrections

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