Document Detail


Selected events following insertion of the Progestasert system.
MedLine Citation:
PMID:  7428359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidences of selected events were analyzed following insertion of the PROGESTASERT intrauterine progesterone contraceptive system (IPCS) and following its reinsertion after one year of use. Reinsertion did not interrupt the stabilizing or declining trends in incidences of P.I.D., removals for bleeding/pain, removals for other medical reasons, unplanned pregnancies, moderate/severe menstrual cramps and bleeding, and premenstrual/intermenstrual cramps. Comparison of the incidence of P.I.D. in the U.S. population with postinsertion incidence of P.I.D. in IPCS users indicates that the IPCS does not increase the likelihood that a woman will have P.I.D. over the likelihood that she would have it without use of the IPCS. The incidences of expulsions and intermenstrual spotting and bleeding rose temporarily after reinsertion to about half their previous peaks and then diminished markedly within two months, reverting to the levels and favorable patterns of change established during the first year.
Phase 3 clinical trials (carried out during 1972-1976) of the Progestasert IUD system are reported. In addition, reinsertion was made 1 year later, and side effects associated with both the initial and reinsertion are reported and compared. Reinsertion did not interrupt the stabilizing or declining trends in incidences of pelvic inflammatory disease, removals for bleeding/pain, removals for other medical indications, or removals for pregnancies. In addition, reinsertion did not affect trends pertaining to moderate/severe menstrual cramps/bleeding or premenstrual/intermenstrual cramping incidence. Incidence of pelvic inflammatory disease, when this series is compared with data for the U.S., was not increased among users of the Progestasert IUD system. However after reinsertion, the incidences of expulsions and intermenstrual spotting and bleeding did rise temporarily to about half their previous peaks with initial insertion, but they diminished markedly within 2 months of reinsertion and reverted to levels and favorable patterns of change which had been established during the first year of IUD use.
Authors:
Y Gibor; C Mitchell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contraception     Volume:  21     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1980 May 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-503     Citation Subset:  IM; J    
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Intrauterine Devices, Medicated / adverse effects*
Menstruation Disturbances / etiology
Pelvic Inflammatory Disease / etiology*
Pregnancy
Progesterone / adverse effects*
Chemical
Reg. No./Substance:
57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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