Document Detail

Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans.
MedLine Citation:
PMID:  9858614     Owner:  NLM     Status:  MEDLINE    
HCF is a mammalian nuclear protein that undergoes proteolytic processing and is required for cell proliferation. During productive herpes simplex virus (HSV) infection, the viral transactivator VP16 associates with HCF to initiate HSV gene transcription. Here, we show that the worm Caenorhabditis elegans possesses a functional homolog of mammalian HCF that can associate with and activate the viral protein VP16. The pattern of sequence conservation, however, is uneven. Sequences required for mammalian HCF processing are not present in C. elegans HCF. Furthermore, not all elements of mammalian HCF that are required for promoting cell proliferation are conserved. Nevertheless, unexpectedly, C. elegans HCF can promote mammalian cell proliferation because a region of HCF that is conserved can promote mammalian cell proliferation better than its human counterpart. These results suggest that HCF possesses a highly conserved role in metazoan cell proliferation which is targeted by VP16 to regulate HSV infection. The precise mechanisms, however, by which HCF functions in mammals and worms appear to differ.
Y Liu; M O Hengartner; W Herr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular biology     Volume:  19     ISSN:  0270-7306     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  909-15     Citation Subset:  IM    
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Caenorhabditis elegans / genetics,  metabolism*
Caenorhabditis elegans Proteins
Cell Division
DNA, Helminth
Gene Expression Regulation
Helminth Proteins / genetics,  metabolism*
Herpes Simplex Virus Protein Vmw65 / metabolism*
Host Cell Factor C1
Molecular Sequence Data
Proteins / genetics,  metabolism*
Sequence Homology, Amino Acid
Transcription Factors*
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/DNA, Helminth; 0/HCFC1 protein, human; 0/Helminth Proteins; 0/Herpes Simplex Virus Protein Vmw65; 0/Host Cell Factor C1; 0/Proteins; 0/Transcription Factors; 0/hcf-1 protein, C elegans

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