| Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. | |
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MedLine Citation:
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PMID: 12015388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is a misbelief that the same animal has the same thermoneutral zone (TNZ) in different experimental setups. In reality, TNZ strongly depends on the physical environment and varies widely across setups. Current methods for determining TNZ require elaborate equipment and can be applied only to a limited set of experimental conditions. A new, broadly applicable approach that rapidly determines whether given conditions are neutral for a given animal is needed. Consistent with the definition of TNZ [the range of ambient temperature (T(a)) at which body core temperature (T(c)) regulation is achieved only by control of sensible heat loss], we propose three criteria of thermoneutrality: 1) the presence of high-magnitude fluctuations in skin temperature (T(sk)) of body parts serving as specialized heat exchangers with the environment (e.g., rat tail), 2) the closeness of T(sk) to the median of its operational range, and 3) a strong negative correlation between T(sk) and T(c). Thermocouple thermometry and liquid crystal thermography were performed in five rat strains at 13 T(a). Under the conditions tested (no bedding or filter tops, no group thermoregulation), the T(a) range of 29.5-30.5 degrees C satisfied all three TNZ criteria in Wistar, BDIX, Long-Evans, and Zucker lean rats; Zucker fatty rats had a slightly lower TNZ (28.0-29.0 degrees C). Skin thermometry or thermography is a definition-based, simple, and inexpensive technique to determine whether experimental or housing conditions are neutral, subneutral, or supraneutral for a given animal. |
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Authors:
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Andrej A Romanovsky; Andrei I Ivanov; Yury P Shimansky |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 92 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-16 Completed Date: 2002-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 2667-79 Citation Subset: IM |
Affiliation:
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Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA. aromano@chw.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / physiology* Male Models, Theoretical Obesity / physiopathology Rats / physiology* Rats, Inbred Strains / physiology Skin Temperature Temperature* Thermography Thermometers |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS-41233/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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