| Selected sun-sensitizing medications and incident cataract. | |
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MedLine Citation:
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PMID: 20547934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the relationship between the use of sun-sensitizing medications and cumulative incidence of age-related cataract. METHODS: Sun exposure was estimated from residential history of adults in the Midwestern community of Beaver Dam, Wisconsin, which permitted calculation of Wisconsin sun-years at the baseline examination. Medication history was reported at each examination. Cataract presence was determined by standardized lens photographs that were taken at each examination and graded according to standard protocols. RESULTS: No significant effects were noted of Wisconsin sun-year exposure or use of sun-sensitizing medications on the cumulative incidence of any type of age-related cataract when controlling for age and sex. However, an interaction term combining Wisconsin sun-years and use of any sun-sensitizing medication was significant (P = .04) such that risk of cortical cataract is significantly higher for the joint risk group. Further controlling for the presence of diabetes mellitus, history of heavy drinking, and hat or sunglasses use did not alter the relationships. CONCLUSIONS: Data suggest that the use of sun-sensitizing medications interacts with sun exposure to influence the risk of cortical cataract, a common age-related cataract. If confirmed, this finding may have important implications for medication use. |
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Authors:
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Barbara E K Klein; Kristine E Lee; Lorraine G Danforth; Tracie M Schaich; Karen J Cruickshanks; Ronald Klein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-14 |
Journal Detail:
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Title: Archives of ophthalmology Volume: 128 ISSN: 1538-3601 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-08-26 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 959-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726-2336, USA. kleinb@epi.ophth.wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cataract / epidemiology* Drug Utilization Female Humans Incidence Lens, Crystalline / drug effects*, radiation effects* Male Middle Aged Photosensitizing Agents / therapeutic use* Sunlight* Ultraviolet Rays* Wisconsin / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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EY06594/EY/NEI NIH HHS; U10 EY006594-20/EY/NEI NIH HHS; U10 EY006594-21A1/EY/NEI NIH HHS; U10 EY006594-21A1S1/EY/NEI NIH HHS; U10 EY006594-22/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents |
| Comments/Corrections | |
Comment In:
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Arch Dermatol. 2010 Aug;146(8):835
[PMID:
20713812
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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