Document Detail


Seizures and multiple sclerosis in Chinese patients: A clinical and magnetic resonance imaging study.
MedLine Citation:
PMID:  22503593     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Epileptic seizures in Chinese patients with multiple sclerosis (MS) have not been studied extensively. We investigated the clinical, laboratory, and imaging findings for Chinese patients with MS who had experienced seizures. METHODS: A total of 93 (57.4%) patients were diagnosed as having conventional MS and 69 (42.6%) patients as having neuromyelitis optica (NMO) over 20years. Data on clinical symptoms, related examinations, and treatment were analyzed retrospectively. RESULTS: Eight patients (8.6%), all of whom were female, had seizures during the course of relapsing-remitting MS. One had seizures as the presenting symptom of MS. The seizure type was focal onset in all the 8 patients, 6 of whom had secondarily generalized seizures. Only 1 patient was recorded as having focal epileptiform discharges by electroencephalography. The frequency of seizures was significantly higher in patients with recurrent seizures than in those with acute-MS-related seizures. Diffuse or extensive lesions were observed in acute-MS-related seizures; focal persistent lesions were related to recurrent seizures or even status epilepticus, both of which need long-term antiepileptic medication. CONCLUSION: The seizure courses (acute or recurrent) and distribution of lesions (diffuse or localized) might provide information on seizure recurrence and decide antiepileptic treatment strategies.
Authors:
Mei-Yun Cheng; Yau-Yau Wai; Long-Sun Ro; Tony Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-12
Journal Detail:
Title:  Epilepsy research     Volume:  -     ISSN:  1872-6844     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, #5, Fu-Shing Road, Guishan Township, Taoyuan County, Taiwan, ROC.
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