| Seizures induced by penicillin microinjections in the mesencephalic tegmentum. | |
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MedLine Citation:
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PMID: 10604604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The location and extension of a convulsive area in the brain stem in cats was determined through penicillin microinjections (0.5-1.0 microl) of a concentrated sodium penicillin solution (500 IU/microl), stereotactically oriented to multiple structures, in fully awake animals, partially restrained through a rod fixation system that avoided pain, allowed the observation of clinical seizures and simultaneous recording of EEG, EMG and multiple unit activity (MUA) from the injected site and the motor cortex (Cx). Clinical and EEG seizure patterns in relation to the injected sites and penicillin doses were studied in another group of animals using doses from 12.5 IU/0.1 microl to 125 IU/1.0 microl. The time relationship between muscular clonus, EEG spikes and MUA at the injected site and Cx were analyzed. The only area in which penicillin induced seizures was the mesencephalic tegmentum (MT). The amount of penicillin but not the stereotactic coordinates determined the seizure type. MT EEG and MUA paroxysms anticipated clinical seizure and Cx EEG spikes. When Cx EEG appeared, they were accompanied by an increase in MUA beginning in the Cx and EMG, followed by significant increase in MT MUA. The sequence of events suggest that MT seizure activity propagates via alternative pathways not involving direct reticulospinal or pyramidal tract pathways. |
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Authors:
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F Jimenez; F Velasco; J Carrillo-Ruiz; F E Villanueva; M Velasco; H Ponce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsy research Volume: 38 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-01-24 Completed Date: 2000-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 33-44 Citation Subset: IM |
Affiliation:
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Unit of Neurology, General Hospital and Children's Hospital SS and Medical Research Department, National Medical Center IMSS, Mexico, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Dose-Response Relationship, Drug Electroencephalography / drug effects Electromyography / drug effects Hydrogen-Ion Concentration Microinjections Penicillins / administration & dosage, toxicity* Reticular Formation / physiology Seizures / chemically induced*, physiopathology Stereotaxic Techniques Tegmentum Mesencephali / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Penicillins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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