| Seizures in primary antiphospholipid syndrome: the relevance of smoking to stroke. | |
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MedLine Citation:
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PMID: 22489254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations. METHODS: Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated. RESULTS: Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures. CONCLUSION: About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and stroke. |
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Authors:
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Jozélio Freire de Carvalho; Sandra Gofinet Pasoto; Simone Appenzeller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-03-25 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2012 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-10 Completed Date: 2013-03-01 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: Egypt |
Other Details:
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Languages: eng Pagination: 981519 Citation Subset: IM |
Affiliation:
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Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 01246-903 São Paulo, SP, Brazil. jotafc@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Antibodies, Antiphospholipid / blood Antiphospholipid Syndrome / blood, complications*, physiopathology Female Humans Male Middle Aged Regression Analysis Risk Factors Seizures / blood, physiopathology* Smoking / adverse effects* Sneddon Syndrome / blood, etiology, physiopathology Stroke / blood, etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid |
| Comments/Corrections | |
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