Document Detail

Seizures in primary antiphospholipid syndrome: the relevance of smoking to stroke.
MedLine Citation:
PMID:  22489254     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations.
METHODS: Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated.
RESULTS: Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures.
CONCLUSION: About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and stroke.
Jozélio Freire de Carvalho; Sandra Gofinet Pasoto; Simone Appenzeller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-25
Journal Detail:
Title:  Clinical & developmental immunology     Volume:  2012     ISSN:  1740-2530     ISO Abbreviation:  Clin. Dev. Immunol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-10     Completed Date:  2013-03-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101183692     Medline TA:  Clin Dev Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  981519     Citation Subset:  IM    
Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 01246-903 São Paulo, SP, Brazil.
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MeSH Terms
Age of Onset
Antibodies, Antiphospholipid / blood
Antiphospholipid Syndrome / blood,  complications*,  physiopathology
Middle Aged
Regression Analysis
Risk Factors
Seizures / blood,  physiopathology*
Smoking / adverse effects*
Sneddon Syndrome / blood,  etiology,  physiopathology
Stroke / blood,  etiology*,  physiopathology
Reg. No./Substance:
0/Antibodies, Antiphospholipid

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