Document Detail

Seizures in haemodialysis patients treated with recombinant human erythropoietin.
MedLine Citation:
PMID:  2517327     Owner:  NLM     Status:  MEDLINE    
Administration of recombinant erythropoietin (r-HuEPO) is an effective treatment for the anaemia of chronic renal failure, but in some patients it has been accompanied by elevated blood pressure. This study focuses on seven patients with end-stage renal failure, managed on haemodialysis, who developed probable hypertensive encephalopathy with seizures during treatment with r-HuEPO. All made a full recovery. The events were not clearly related to the haemoglobin concentrations achieved, and four patients have subsequently been restarted on r-HuEPO therapy at a reduced dose, resulting in a slower increase in haemoglobin with no recurrence of episodes of severe hypertension. Close attention needs to be paid to blood pressure in patients commencing erythropoietin therapy, and it seems prudent to aim for a gradual increase in haemoglobin concentration to allow the circulation to adapt to changes in oxygen delivery and haematocrit.
M E Edmunds; J Walls; B Tucker; L R Baker; C R Tomson; M Ward; J Cunningham; R Moore; C G Winearls
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  4     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-17     Completed Date:  1990-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1065-9     Citation Subset:  IM    
Department of Nephrology, Leicester General Hospital, UK.
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MeSH Terms
Blood Pressure / drug effects
Erythropoietin / adverse effects*,  therapeutic use
Hemoglobins / metabolism
Hypertension / chemically induced
Kidney Failure, Chronic / complications
Middle Aged
Recombinant Proteins / adverse effects,  therapeutic use
Renal Dialysis / adverse effects*
Seizures / chemically induced*
Reg. No./Substance:
0/Hemoglobins; 0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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