| Seizures in fragile X syndrome: characteristics and comorbid diagnoses. | |
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MedLine Citation:
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PMID: 20945999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A national survey of caregivers of individuals with fragile X syndrome addressed characteristics of epilepsy and co-occurring conditions. Of the 1,394 individuals (1,090 males and 304 females) with the full mutation, 14% of males and 6% of females reported seizures. Seizures were more often partial, began between ages 4 and 10 years, and were infrequent and easily treated. Similar characteristics and patterns were seen in medical chart review data from a large clinic cohort of patients with fragile X syndrome. National survey data showed that autism was significantly associated with seizures as a co-occurring condition. Although seizures in fragile X syndrome are typically not severe and easily treated with medications, they appear to be associated with developmental–behavioral comorbidity that impacts function. |
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Authors:
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Elizabeth Berry-Kravis; Melissa Raspa; Lisa Loggin-Hester; Ellen Bishop; David Holiday; Donald B Bailey |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal on intellectual and developmental disabilities Volume: 115 ISSN: 1944-7515 ISO Abbreviation: Am J Intellect Dev Disabil Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101492916 Medline TA: Am J Intellect Dev Disabil Country: United States |
Other Details:
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Languages: eng Pagination: 461-72 Citation Subset: IM |
Affiliation:
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Rush University Medical Center, Chicago, IL, USA. Elizabeth_M_Berry-Kravis@rush.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Anticonvulsants / therapeutic use Child Child, Preschool Comorbidity Epilepsy / drug therapy, epidemiology* Family Health Female Fragile X Syndrome / epidemiology* Health Surveys / statistics & numerical data* Humans Male Parents Physicians Prevalence Severity of Illness Index* |
| Grant Support | |
ID/Acronym/Agency:
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U50/CCU300860//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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