Document Detail

Seizures in fragile X syndrome: characteristics and comorbid diagnoses.
MedLine Citation:
PMID:  20945999     Owner:  NLM     Status:  MEDLINE    
A national survey of caregivers of individuals with fragile X syndrome addressed characteristics of epilepsy and co-occurring conditions. Of the 1,394 individuals (1,090 males and 304 females) with the full mutation, 14% of males and 6% of females reported seizures. Seizures were more often partial, began between ages 4 and 10 years, and were infrequent and easily treated. Similar characteristics and patterns were seen in medical chart review data from a large clinic cohort of patients with fragile X syndrome. National survey data showed that autism was significantly associated with seizures as a co-occurring condition. Although seizures in fragile X syndrome are typically not severe and easily treated with medications, they appear to be associated with developmental–behavioral comorbidity that impacts function.
Elizabeth Berry-Kravis; Melissa Raspa; Lisa Loggin-Hester; Ellen Bishop; David Holiday; Donald B Bailey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal on intellectual and developmental disabilities     Volume:  115     ISSN:  1944-7515     ISO Abbreviation:  Am J Intellect Dev Disabil     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101492916     Medline TA:  Am J Intellect Dev Disabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-72     Citation Subset:  IM    
Rush University Medical Center, Chicago, IL, USA.
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MeSH Terms
Age of Onset
Anticonvulsants / therapeutic use
Child, Preschool
Epilepsy / drug therapy,  epidemiology*
Family Health
Fragile X Syndrome / epidemiology*
Health Surveys / statistics & numerical data*
Severity of Illness Index*
Grant Support
U50/CCU300860//PHS HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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