| Seizures in children with low-grade tumors: outcome after tumor resection and risk factors for uncontrolled seizures. | |
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MedLine Citation:
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PMID: 16776371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: The goals of this study were to define the incidence of seizures in children with low-grade tumors, study seizure outcome after lesionectomy in these children, and identify risk factors for poor seizure outcome. METHODS: The authors performed a retrospective chart review of children who harbored low-grade brain tumors, experienced seizures, and were treated in a single institution. Statistical analyses included step-wise as well as single-variable binary logistic regression analyses. Fifty-five children (20%) with seizures were identified in a cohort of 280 children with low-grade tumors. Of these 55 children, 35 harbored cortical cerebral tumors and 20 had noncortical lesions, including six whose tumors were in the posterior fossa. Seizures were defined as controlled if there was no seizure in the 12 months preceding the last clinic visit. All cortical tumors were treated by lesionectomy as an initial procedure. Of the 27 children with cortical tumors whose seizures began before tumor diagnosis, 23 had complete resection and 52% of these 23 experienced no further seizures after surgery. Seizures are presently controlled in 84% of the total 55 patients at a median follow-up time of 4.5 years after the first seizure (range 1-17.4 years). Only two variables, a pericavity hyperintense signal on T2-weighted magnetic resonance (MR) images and at least 10 seizures prior to therapy for seizures, were associated with uncontrolled seizures. CONCLUSIONS: Lesionectomy may be appropriate in children with low-grade brain tumors. A large number of seizures before therapy and a hyperintense area around the tumor cavity on postresection MR images are associated with uncontrolled seizures. Medical therapy and tumor resection will control seizures in the majority of children with low-grade tumors. |
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Authors:
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Raja B Khan; Frederick A Boop; Arzu Onar; Robert A Sanford |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 104 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-16 Completed Date: 2006-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
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Languages: eng Pagination: 377-82 Citation Subset: AIM; IM |
Affiliation:
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Departments of Radiological Sciences, Biostatistics, and Neuro-surgical Service, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. raja.khan@stjude.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain Neoplasms / pathology, surgery* Child Child, Preschool Female Follow-Up Studies Humans Infant Male Neoplasms, Neuroepithelial / pathology, surgery* Papilloma, Choroid Plexus / pathology, surgery* Retrospective Studies Risk Factors Seizures / etiology*, prevention & control* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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