Document Detail


Seizures in extremely low birth weight infants are associated with adverse outcome.
MedLine Citation:
PMID:  20542294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine risk factors for neonatal clinical seizures and to determine the independent association with death or neurodevelopmental impairment (NDI) in extremely low birth weight (ELBW) infants.
STUDY DESIGN: A total of 6499 ELBW infants (401-1000 g) surviving to 36 weeks postmenstrual age (PMA) were included in this retrospective study. Unadjusted comparisons were performed between infants with (n = 414) and without (n = 6085) clinical seizures during the initial hospitalization. Using multivariate logistic regression modeling, we examined the independent association of seizures with late death (after 36 weeks PMA) or NDI after controlling for multiple demographic, perinatal, and neonatal variables.
RESULTS: Infants with clinical seizures had a greater proportion of neonatal morbidities associated with poor outcome, including severe intraventricular hemorrhage, sepsis, meningitis, and cystic periventricular leukomalacia (all P < .01). Survivors were more likely to have NDI or moderate-severe cerebral palsy at 18 to 22 months corrected age (both P < .01). After adjusting for multiple confounders, clinical seizures remained significantly associated with late death or NDI (odds ratio, 3.15; 95% CI, 2.37-4.19).
CONCLUSION: ELBW infants with clinical seizures are at increased risk for adverse neurodevelopmental outcome, independent of multiple confounding factors.
Authors:
Alexis S Davis; Susan R Hintz; Krisa P Van Meurs; Lei Li; Abhik Das; Barbara J Stoll; Michele C Walsh; Athina Pappas; Edward F Bell; Abbot R Laptook; Rosemary D Higgins;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-14
Journal Detail:
Title:  The Journal of pediatrics     Volume:  157     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-02     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-5.e1-2     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Developmental Disabilities / epidemiology,  etiology
Humans
Infant, Extremely Low Birth Weight*
Infant, Newborn
Nervous System Diseases / epidemiology,  etiology
Prognosis
Retrospective Studies
Risk Factors
Seizures / complications*,  epidemiology*
Time Factors
Grant Support
ID/Acronym/Agency:
M01 RR000080/RR/NCRR NIH HHS; M01 RR16587/RR/NCRR NIH HHS; M01 RR30/RR/NCRR NIH HHS; M01 RR32/RR/NCRR NIH HHS; M01 RR39/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR633/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR750/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; M01 RR997/RR/NCRR NIH HHS; M01RR6022/RR/NCRR NIH HHS; MO1 RR125/RR/NCRR NIH HHS; U01 HD36790/HD/NICHD NIH HHS; U10 HD021364-25/HD/NICHD NIH HHS; U10 HD021385-21/HD/NICHD NIH HHS; U10 HD027853/HD/NICHD NIH HHS; U10 HD027904-10/HD/NICHD NIH HHS; U10 HD034216-15/HD/NICHD NIH HHS; U10 HD040492/HD/NICHD NIH HHS; U10 HD040521/HD/NICHD NIH HHS; U10 HD040689-02/HD/NICHD NIH HHS; U10 HD053089/HD/NICHD NIH HHS; U10 HD053109-05/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD21415/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; U10 HD53089/HD/NICHD NIH HHS; U10HD34216/HD/NICHD NIH HHS; U10HD40492/HD/NICHD NIH HHS; UL1 RR024139-01/RR/NCRR NIH HHS; UL1 RR24139/RR/NCRR NIH HHS
Investigator
Investigator/Affiliation:
Alan H Jobe / ; Michael S Caplan / ; Avroy A Fanaroff / ; Deanne E Wilson-Costello / ; Nancy S Newman / ; Bonnie S Siner / ; Kurt Schibler / ; Edward F Donovan / ; Jean J Steichen / ; Kimberly Yolton / ; Kate Bridges / ; Barbara Alexander / ; Teresa L Gratton / ; Cathy Grisby / ; Marcia Worley Mersmann / ; Holly L Mincey / ; Jody Hessling / ; Ronald N Goldberg / ; Ricki F Goldstein / ; C Michael Cotten / ; Kimberley A Fisher / ; Kathryn E Gustafson / ; Melody B Lohmeyer / ; David P Carlton / ; Ira Adams-Chapman / ; Linda Black / ; Ann M Blackwelder / ; Sheena Carter / ; Elisabeth Dinkins / ; Ellen C Hale / ; Judson Miller / ; Maureen Mulligan LaRossa / ; Irma Seabrook / ; Gloria V Smikle / ; Linda L Wright / ; Elizabeth M McClure / ; Stephanie Archer / ; Brenda B Poindexter / ; James A Lemons / ; Ann B Cook / ; Anna M Dusick / ; Dianne E Herron / ; Lucy C Miller / ; Heike M Minnich / ; Leslie Richard / ; Leslie Dawn Wilson / ; Faithe Hamer / ; W Kenneth Poole / ; Betty K Hastings / ; Elizabeth M McClure / ; Margaret Cunningham / ; Jeanette O'Donnell Auman / ; Jamie E Newman / ; Carolyn Petrie Huitema / ; Kristin M Zaterka-Baxter / ; David K Stevenson / ; Marian M Adams / ; M Bethany Ball / ; Joan M Baran / ; Ginger K Brudos / ; Anne M DeBattista / ; Dharshi Sivakumar / ; Nicholas H St John / ; Waldemar A Carlo / ; Myriam Peralta-Carcelen / ; Amanda Soong / ; Monica V Collins / ; Shirley S Cosby / ; Kirstin J Bailey / ; Fred J Biasini / ; Stephanie A Chopko / ; Mary Beth Moses / ; Kathleen G Nelson / ; Vivien A Phillips / ; Julie Preskitt / ; Richard V Rector / ; Sally Whitley / ; Neil N Finer / ; Paul R Wozniak / ; Maynard R Rasmussen / ; Yvonne E Vaucher / ; Kathy Arnell / ; Clarence Demetrio / ; Chris Henderson / ; Wade Rich / ; Rene Barbieri-Welge / ; Ayala Ben-Tall / ; Martha G Fuller / ; Elaine Ito / ; Meghan Lukasik / ; Deborah Pontillo / ; Donna Posin / ; Cheryl Runyan / ; James Wilkes / ; Shahnaz Duara / ; Charles R Bauer / ; Ruth Everett-Thomas / ; Maria Calejo / ; Alexis N Diaz / ; Silvia M Frade Eguaras / ; Yamiley Gideon / ; Kasey Hamlin-Smith / ; Sylvia Hiriart-Fajardo / ; Lisa Jean-Gilles / ; Ann Londono / ; Elaine O Mathews / ; Amy Mur Worth / ; Alexandra Stroerger / ; Kristi L Watterberg / ; LuAnn Papile / ; Janell Fuller / ; Conra Backstrom Lacy / ; Debra V Long / ; Jean Lowe / ; Rebecca Montman / ; Julie Rohr / ; Dale L Phelps / ; Gary J Myers / ; Linda J Reubens / ; Erica Burnell / ; Julie Babish Johnson / ; Diane Hust / ; Rosemary L Jensen / ; Emily Kushner / ; Joan Merzbach / ; Kelley Yost / ; Sheldon B Korones / ; Henrietta S Bada / ; Tina Hudson / ; Marilyn Williams / ; Kimberly Yolton / ; Pablo J Sánchez / ; Charles R Rosenfeld / ; Walid A Salhab / ; R Sue Broyles / ; Roy J Heyne / ; Sally S Adams / ; Cristin Dooley / ; Gaynelle Hensley / ; Elizabeth Heyne / ; Jackie F Hickman / ; Linda A Madden / ; Susie Madison / ; Nancy A Miller / ; Janet S Morgan / ; Alicia Guzman / ; Catherine Twell Boatman / ; Kathleen A Kennedy / ; Jon E Tyson / ; Pamela J Bradt / ; Patricia W Evans / ; Esther G Akpa / ; Nora Alaniz / ; Patty A Cluff / ; Susan Dieterich / ; Claudia I Franco / ; Anna E Lis / ; Terri Major-Kincade / ; Georgia E McDavid / ; Brenda H Morris / ; Maegan C Simmons / ; Patti Pierce Tate / ; Stacey Reddoch / ; Laura L Whitely / ; Sharon Wright / ; T Michael O'Shea / ; Robert G Dillard / ; Nancy J Peters / ; Deborah Evans Allred / ; Donald J Goldstein / ; Barbara G Jackson / ; Carroll Peterson / ; Ellen L Waldrep / ; Melissa Whalen Morris / ; Gail Wiley Hounshell / ; Seetha Shankaran / ; Virginia Delaney-Black / ; Yvette R Johnson / ; Rebecca Bara / ; Geraldine Muran / ; Deborah Kennedy / ; Laura Goldston / ; William Oh / ; Betty R Vohr / ; Bonnie E Stephens / ; Angelita M Hensman / ; Barbara Alksninis / ; Bill Cashore / ; Theresa M Leach / ; Martha R Leonard / ; Kalida Mehta / ; Lucy Noel / ; Suzy Ventura / ; Victoria E Watson / ; Richard A Ehrenkranz / ; Patricia Gettner / ; Monica Konstantino / ; JoAnn Poulsen / ; Janet Taft / ; Nancy Close / ; Elaine Romano / ; Joanne Williams /
Comments/Corrections
Comment In:
J Pediatr. 2010 Nov;157(5):700-1   [PMID:  20813380 ]

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