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Seizures in Acute Stroke: Incidence, Risk Factors and Prognosis.
MedLine Citation:
PMID:  22777596     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Purpose: Studies on post-stroke seizures have produced conflicting results. Our study aim was to further elucidate the incidence and predictive factors of early post-stroke seizures (ES) and their relationship with outcome. Methods: relevant clinical data were prospectively collected in 2,053 patients with acute stroke admitted to the Stroke Unit from 2004 to 2008. Results: Sixty-six patients (8 hemorrhagic and 58 ischemic strokes) aged 73-88 years (mean age 82 years) presented seizures in the first week after stroke onset. The type of ischemic stroke was atherothrombotic in 10 patients, cardioembolic in 21, lacunar in 4, undetermined in 19, and of other etiology in 4. Twenty-seven patients had generalized convulsive, 6 had complex partial, and 33 had simple partial seizures. Status epilepticus was observed in 13 patients. The severity of strokes in patients with ES was greater than in those without (National Institutes of Health Stroke Scale >14 in 50 vs. 25%), so mortality (30 days) was higher (29 vs. 14%). Independent seizure predictors were: total anterior circulation infarct, hemorrhagic transformation, hyperglycemia, and the interaction term diabetes × hyperglycemia. Conclusions: ES may be considered a marker of stroke severity. Cortical location of the lesion, hemorrhagic transformation, and hyperglycemia in patients without diabetes are important predictors of ES.
Authors:
Gaetano Procaccianti; Anna Zaniboni; Francesca Rondelli; Michela Crisci; Tommaso Sacquegna
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-05
Journal Detail:
Title:  Neuroepidemiology     Volume:  39     ISSN:  1423-0208     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  45-50     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Neurologia-Stroke Unit, Ospedale Maggiore, IRCCS, Istituto di Scienze neurologiche, Bologna, Italy.
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