Document Detail


Seizures-evoked activation of transcription factors.
MedLine Citation:
PMID:  8053414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chemically provoked seizures have proved to serve as useful model to investigate long term neuronal responses collectively termed as neuronal plasticity. In particular, rapid, transient activation of immediate early gene expression induced by such chemoconvulsants like pentylenetetrazole (PTZ) and kainic acid (KA) drew a great attention. These genes code for transcription factors, known to influence gene expression, and therefore able to orchestrate genomic responses to extracellular stimuli. In our studies reviewed herein and reported in detail elsewhere, we have investigated PTZ- and KA-dependent activation of a functional feature of transcription factors i.e. their DNA-binding activity. We have found that only AP-1 DNA-binding activity was elevated in the rat hippocampus, entorhinal and sensory cortices 2-6 h after the PTZ administration, and only in the hippocampus and entorhinal cortex at similar times following KA injection. The AP-1 response to PTZ was strikingly enhanced in aged (18-24 months old) animals when compared to young (3 months old) ones. KA, apart from this early phase of AP-1 DNA-binding activity increase, evoked also the late one (reaching a peak value at 72 h). The protein composition of the latter differed from the former mostly by substitution of Jun B with Jun D protein and lack of c-Fos. Because the KA treatment leads not only to the seizures but to apoptosis (programmed cell death) as well, our results indicate that various AP-1 complexes may be involved in both of these phenomenon.
Authors:
B Kamińska; K Lukasiuk; L Kaczmarek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  54     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-06     Completed Date:  1994-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Affiliation:
Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology
DNA / metabolism
Kainic Acid
Pentylenetetrazole
Protein Binding
Proto-Oncogene Proteins c-jun / metabolism
Rats
Seizures / chemically induced,  metabolism*,  pathology
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-jun; 0/Transcription Factors; 487-79-6/Kainic Acid; 54-95-5/Pentylenetetrazole; 9007-49-2/DNA

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