Document Detail

Seizures-evoked activation of transcription factors.
MedLine Citation:
PMID:  8053414     Owner:  NLM     Status:  MEDLINE    
Chemically provoked seizures have proved to serve as useful model to investigate long term neuronal responses collectively termed as neuronal plasticity. In particular, rapid, transient activation of immediate early gene expression induced by such chemoconvulsants like pentylenetetrazole (PTZ) and kainic acid (KA) drew a great attention. These genes code for transcription factors, known to influence gene expression, and therefore able to orchestrate genomic responses to extracellular stimuli. In our studies reviewed herein and reported in detail elsewhere, we have investigated PTZ- and KA-dependent activation of a functional feature of transcription factors i.e. their DNA-binding activity. We have found that only AP-1 DNA-binding activity was elevated in the rat hippocampus, entorhinal and sensory cortices 2-6 h after the PTZ administration, and only in the hippocampus and entorhinal cortex at similar times following KA injection. The AP-1 response to PTZ was strikingly enhanced in aged (18-24 months old) animals when compared to young (3 months old) ones. KA, apart from this early phase of AP-1 DNA-binding activity increase, evoked also the late one (reaching a peak value at 72 h). The protein composition of the latter differed from the former mostly by substitution of Jun B with Jun D protein and lack of c-Fos. Because the KA treatment leads not only to the seizures but to apoptosis (programmed cell death) as well, our results indicate that various AP-1 complexes may be involved in both of these phenomenon.
B Kamińska; K Lukasiuk; L Kaczmarek
Related Documents :
9589694 - Cellular localization of c-jun messenger ribonucleic acid and protein and their relatio...
8134124 - Protein kinase a and ap-1 (c-fos/jund) are induced during apoptosis of mouse mammary ep...
8241024 - Chimeras of herpes simplex viral vp16 and jun are oncogenic.
8264634 - C-jun inhibits transcriptional activation by the insulin enhancer, and the insulin cont...
17073554 - Genetics and genomics of osteoclast differentiation: integrating cell signaling pathway...
3612804 - Sense and antisense transcription of bacteriophage t4 gene 32. processing and stability...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  54     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  1994  
Date Detail:
Created Date:  1994-09-06     Completed Date:  1994-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / pathology
DNA / metabolism
Kainic Acid
Protein Binding
Proto-Oncogene Proteins c-jun / metabolism
Seizures / chemically induced,  metabolism*,  pathology
Transcription Factors / metabolism*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-jun; 0/Transcription Factors; 487-79-6/Kainic Acid; 54-95-5/Pentylenetetrazole; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Individual differences in the functional asymmetry of the human brain.
Next Document:  Expression of astroglial nerve growth factor in damaged brain.