Document Detail

Seizures associated with poisoning in children: tricyclic antidepressant intoxication.
MedLine Citation:
PMID:  17168978     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to examine the characteristics of seizure due to poisoning. METHODS: This was a retrospective analysis, throughout 4 years of hospital admissions for poisoning. Data of patients with seizures due to poisoning were evaluated with respect to the causes, frequencies and complications of seizures. RESULTS: Among the 1561 admissions due to intoxication during the review period, seizures developed in 26 cases (1.6%). Tricyclic antidepressant overdose (n = 11, 42%) was the leading cause of seizure due to poisoning. Generalized tonic-clonic seizures were observed in 24 patients. Status epilepticus developed in six patients (23%). Mechanical ventilation was applied in 12 (46%) patients. Cardiac complications were observed in 11 (42%) patients with seizures. Two patients who had cardiac arrest due to acepromazine maleate and imipramine intoxication died. CONCLUSION: One of the causes of seizures in pediatric age group is intoxication. Seizures due to intoxications may cause serious clinical conditions. Intoxications should be thought when a patient is admitted with the diagnosis of afebrile seizure even if there is no history of drug intake.
Agop Citak; Demet Demirkol Soysal; Raif Uçsel; Metin Karaböcüoglu; Nedret Uzel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  48     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-01-24     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  582-5     Citation Subset:  IM    
Department of Pediatric Emergency, Institute of Child Health, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Antidepressive Agents, Tricyclic / poisoning*
Child, Preschool
Medical Records
Retrospective Studies
Seizures / chemically induced*,  epidemiology*,  mortality,  therapy
Survival Analysis
Turkey / epidemiology
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic

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