| Seizure resulting from a venlafaxine overdose. | |
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MedLine Citation:
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PMID: 9034419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of venlafaxine overdose. CASE SUMMARY: A 40-year-old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt. After the ingestion of 26 venlafaxine 50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical intensive care unit, venlafaxine was discontinued, and no further sequelae were seen. DISCUSSION: To our knowledge, this is the first reported case of venlafaxine overdose that resulted in a generalized seizure. Based on nonoverdose pharmacokinetics and pharmacodynamics of venlafaxine and the potential risks of available interventions, no emergent therapy was instituted. CONCLUSIONS: The venlafaxine overdose in our patient resulted in a single episode of generalized seizure but elicited no further sequelae. |
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Authors:
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C M White; R A Gailey; G M Levin; T Smith |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 31 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-05-13 Completed Date: 1997-05-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 178-80 Citation Subset: IM |
Affiliation:
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Drug Information Center, Hartford Hospital, CT 06102, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / poisoning* Cyclohexanols / poisoning* Drug Interactions Female Humans Monoamine Oxidase Inhibitors / adverse effects Overdose Phenelzine / adverse effects Seizures / chemically induced* Suicide, Attempted |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Cyclohexanols; 0/Monoamine Oxidase Inhibitors; 51-71-8/Phenelzine; 93413-69-5/venlafaxine |
| Comments/Corrections | |
Comment In:
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Ann Pharmacother. 1997 Jun;31(6):790-1
[PMID:
9184731
]
Ann Pharmacother. 1998 Jan;32(1):135-6 [PMID: 9475842 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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