Document Detail

Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis.
MedLine Citation:
PMID:  17621516     Owner:  NLM     Status:  MEDLINE    
This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years. Infants with neonatal seizures during a 12-year period were identified retrospectively (n = 146), and data were obtained by medical chart review. Outcomes were ascertained by standardized telephone survey. Thirty-three infants (23%) were taking phenobarbital, and 99 infants (68%) were taking no anticonvulsants at discharge. Comparisons were made between these 2 groups. Phenobarbital prophylaxis did not improve neurologic outcomes, either with respect to seizure recurrence or neurologic development. These data have important implications at a time when many are questioning the practice of prophylaxis after neonatal seizures and when newer anticonvulsants are being recommended for treatment of acute neonatal seizures.
Ronnie Guillet; Jennifer Kwon
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of child neurology     Volume:  22     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-07-10     Completed Date:  2007-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  389-95     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, Golisano Children's Hospital, New York 14642, USA.
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MeSH Terms
Anticonvulsants / therapeutic use*
Child, Preschool
Developmental Disabilities / etiology,  prevention & control*
Epilepsy, Benign Neonatal / complications
Gestational Age
Infant, Newborn
Longitudinal Studies
Phenobarbital / therapeutic use*
Retrospective Studies
Seizures / epidemiology,  etiology,  prevention & control*
Reg. No./Substance:
0/Anticonvulsants; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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