| Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. | |
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MedLine Citation:
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PMID: 17621516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years. Infants with neonatal seizures during a 12-year period were identified retrospectively (n = 146), and data were obtained by medical chart review. Outcomes were ascertained by standardized telephone survey. Thirty-three infants (23%) were taking phenobarbital, and 99 infants (68%) were taking no anticonvulsants at discharge. Comparisons were made between these 2 groups. Phenobarbital prophylaxis did not improve neurologic outcomes, either with respect to seizure recurrence or neurologic development. These data have important implications at a time when many are questioning the practice of prophylaxis after neonatal seizures and when newer anticonvulsants are being recommended for treatment of acute neonatal seizures. |
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Authors:
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Ronnie Guillet; Jennifer Kwon |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of child neurology Volume: 22 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-07-10 Completed Date: 2007-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 389-95 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Neonatology, Golisano Children's Hospital, New York 14642, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use* Child Child, Preschool Developmental Disabilities / etiology, prevention & control* Epilepsy, Benign Neonatal / complications Female Gestational Age Humans Infant Infant, Newborn Longitudinal Studies Male Phenobarbital / therapeutic use* Recurrence Retrospective Studies Seizures / epidemiology, etiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 50-06-6/Phenobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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