Document Detail

Seizure-like activity and glutamate receptors in hippocampal neurons in culture.
MedLine Citation:
PMID:  1979676     Owner:  NLM     Status:  MEDLINE    
Hippocampal neurons that were grown for prolonged periods in the continuous presence of agents that interfere with synaptic transmission, especially excitatory synaptic transmission, appeared to become seizure-prone. Washout of the synaptic blocking agents, that had been continuously present for several weeks to several months, caused the population of neurons to produce an abnormal and intense electrical activity. This consisted of two major components: spontaneously arising phasic responses that closely resembled paroxysmal depolarization shifts and, less frequently, slowly rising depolarizations similar to the sustained depolarizations observed during ictus-like episodes in intact cortex or cortical slices. We describe here observations on the role of the N-methyl-D-aspartate (NMDA) and non-NMDA types of glutamate receptors in the generation of these activities.
W J Koroshetz; E J Furshpan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience research. Supplement : the official journal of the Japan Neuroscience Society     Volume:  13     ISSN:  0921-8696     ISO Abbreviation:  Neurosci. Res. Suppl.     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-29     Completed Date:  1991-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8508422     Medline TA:  Neurosci Res Suppl     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  S65-74     Citation Subset:  IM    
Neurology Department, Massachusetts General Hospital, Boston.
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MeSH Terms
2-Amino-5-phosphonovalerate / pharmacology
Cells, Cultured
Glutamates / metabolism
Hippocampus / metabolism,  pathology,  physiopathology*
Neurons / physiology*
Quinoxalines / pharmacology
Receptors, Glutamate
Receptors, Neurotransmitter / antagonists & inhibitors,  metabolism*
Seizures / physiopathology*
Tetrodotoxin / pharmacology
Reg. No./Substance:
0/Glutamates; 0/Quinoxalines; 0/Receptors, Glutamate; 0/Receptors, Neurotransmitter; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 4368-28-9/Tetrodotoxin; 76726-92-6/2-Amino-5-phosphonovalerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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