Document Detail

Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronounced intra- and extracellular acidosis.
MedLine Citation:
PMID:  2584276     Owner:  NLM     Status:  MEDLINE    
Status epilepticus of greater than 30-min duration in rats gives rise to a conspicuous lesion in the substantia nigra pars reticulata (SNPR) and globus pallidus (GP). The objective of the present study was to explore whether the lesion, which encompasses necrosis of both neurons and glial cells, is related to intra- and extracellular acidosis. Using the flurothyl model previously described to produce seizures, we assessed regional pH values with the autoradiographic 5,5-dimethyl[2-14C]oxazolidine-2,4-dione technique. Regional pH values were assessed in animals with continuous seizures for 20 and 60 min, as well as in those allowed to recover for 30 and 120 min after seizure periods of 20 or 60 min. In additional animals, changes in extracellular fluid pH (pHe) were measured with ion-selective microelectrodes, and extracellular fluid (ECF) volume was calculated from the diffusion profile for electrophoretically administered tetramethylammonium. In structures such as the neocortex and the hippocampus, which show intense metabolic activation during seizures, status epilepticus of 20- and 60-min duration was accompanied by a reduction of the "composite" tissue pH (pHt) of 0.2-0.3 unit. Recovery of pHt was observed upon termination of seizures. In SNPR and in GP, the acidosis was marked to excessive after 20 and 60 min of seizures (delta pHt approximately 0.6 after 60 min).(ABSTRACT TRUNCATED AT 250 WORDS)
K Inamura; M L Smith; A J Hansen; B K Siesjö
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  9     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-29     Completed Date:  1989-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  821-9     Citation Subset:  IM    
Laboratory for Experimental Brain Research, University of Lund, Sweden.
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MeSH Terms
Autoradiography / methods
Brain / pathology,  physiopathology
Carbon Radioisotopes / diagnostic use
Dimethadione / diagnostic use
Globus Pallidus / pathology,  physiopathology*
Hydrogen-Ion Concentration*
Organ Specificity
Rats, Inbred Strains
Status Epilepticus / pathology,  physiopathology*
Substantia Nigra / pathology,  physiopathology*
Grant Support
Reg. No./Substance:
0/Carbon Radioisotopes; 695-53-4/Dimethadione

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