| Seizure-induced c-fos expression in rat medulla oblongata is not dependent on associated elevation of blood pressure. | |
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MedLine Citation:
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PMID: 7478238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was performed to determine whether c-fos immunoreactivity (IR) induced in medulla oblongata by pentylenetetrazole seizures is a consequence of seizure-associated blood pressure elevation and activation of baroreceptor afferent pathways, or occurs independently of hypertension. Immunohistochemical study of sections of medulla oblongata revealed that seizures are followed by induction of c-fos IR in nucleus tractus solitarius (NTS), dorsal motor nucleus of the vagus (DMN 10), and ventrolateral medulla (VLM), while there is negligible c-fos IR after saline sham injections. Seizures were associated with blood pressure elevation peaking at 31 +/- 17% (+/- SD) above baseline. Experimental hypertension at a similar level induced by i.p. phenylephrine also resulted in induction of c-fos IR in NTS. When seizures were preceded by antihypertensive treatment with the alpha-adrenergic antagonist, phentolamine, peak blood pressure tended to remain near the baseline level and lower than sham-injected controls. Normotensive seizures were associated with c-fos IR in NTS, DMN 10, and VLM similar to the pattern following hypertensive seizures. Seizure-induced activation of c-fos IR occurred despite normal blood pressure, and thus can be attributed to a direct effect of the seizure, and not to an indirect effect mediated by hypertension. |
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Authors:
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R K Kanter; J A Strauss; M D Sauro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 194 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-12-07 Completed Date: 1995-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 201-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, SUNY Health Science Center, Syracuse 13210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways Animals Blood Pressure / drug effects Gene Expression Immunohistochemistry Medulla Oblongata / metabolism* Phenylephrine / pharmacology Pressoreceptors Proto-Oncogene Proteins c-fos / biosynthesis*, immunology Rats Rats, Sprague-Dawley Seizures / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-fos; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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