| Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. | |
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MedLine Citation:
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PMID: 21801169 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy. In this and other experimental models, behaviorally monitored seizure frequency was suggested to vary in a circadian fashion, and to increase with time. We re-addressed those hypotheses using continuous video-electroencephalography (EEG) telemetry in rats with SE at 30 days of age. In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm. |
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Authors:
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Rika Bajorat; Marleen Wilde; Tina Sellmann; Timo Kirschstein; Rüdiger Köhling |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-29 |
Journal Detail:
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Title: Epilepsia Volume: - ISSN: 1528-1167 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Wiley Periodicals, Inc. © 2011 International League Against Epilepsy. |
Affiliation:
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Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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