Document Detail

Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures.
MedLine Citation:
PMID:  8536677     Owner:  NLM     Status:  MEDLINE    
Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man. As part of a placebo-controlled double-blind study, patients suffering from intractable complex partial seizures with or without secondary generalization were followed with lumbar punctures at baseline and after three months of GBP treatment (900 mg/day or 1200 mg/day). Cerebrospinal fluid (CSF) was analyzed for concentrations of GBP, amino acids including GABA, homovanillic acid (HVA), and 5 hydroxyindoleacetic acid (5-HIAA). The results indicate that there were no changes in the selected amino acids, HVA, or 5-HIAA after GBP treatment. At steady state the CSF/plasma ratios of GBP ranged from 0.056 to 0.34, indicating that there may be some type of active out-transport of GBP across the blood-brain barrier. No linear relationship was observed between plasma and CSF levels in these patients.
E Ben-Menachem; B Söderfelt; A Hamberger; T Hedner; L I Persson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsy research     Volume:  21     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-02-07     Completed Date:  1996-02-07     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Department of Neurology, University of Göteborg, Sweden.
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MeSH Terms
Acetates / cerebrospinal fluid*,  pharmacology*
Anticonvulsants / cerebrospinal fluid*,  pharmacology*
Cyclohexanecarboxylic Acids*
Dose-Response Relationship, Drug
Epilepsy, Complex Partial / drug therapy*
Follow-Up Studies
Placebo Effect
Seizures / physiopathology*
Time Factors
Treatment Outcome
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Acetates; 0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

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